CVD INFLUENZA 6000

CVD 流感 6000

• 批准号: 7376956
• 负责人: JAMES D CAMPBELL
• 金额: $ 45.75万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376956
• 关键词: CVD; INFLUENZA; 6000

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Influenza (the flu) is a common infection caused by several related viruses. It is responsible for 20,000-40,000 deaths each year in the United States. When a new strain of flu infects people, the infection can spread around the world quickly. This worldwide spread is called a pandemic. Several pandemics have occurred in the last 100 years. These pandemics caused infection and death in a high number of people. In 1918, nearly 40 million people died in a flu pandemic. Some of the new human flu viruses come from bird flu viruses (also known as avian flu). Recently, some strains of bird flu viruses have infected people in Asia and caused a number of deaths. One of these flu strains is called A/H5N1. There is concern this new strain could cause a pandemic. Vaccines can prevent infection and disease. Vaccines work by causing the body to make proteins called antibodies that fight infection. Sometimes more than 1 dose of vaccine is needed so that the body will make enough antibodies to fight infection. Vaccines have already been developed to prevent infection with "regular" flu viruses. These flu vaccines protect against flu and the health problems it causes. They are made from parts of killed flu virus and are given as a "shot" in the arm. We are conducting this research study using a killed flu virus vaccine against the bird flu virus, A/H5N1. This vaccine is considered investigational. It has never been tested in humans. This vaccine was made the same way as "regular" flu vaccine that is given to people every year before flu season. In this study, we are trying to find out what strength of this vaccine is needed to produce protective levels of "bird flu" antibodies, which will help us decide the right dose for use in the future, if it is needed.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。流感（流感）是由几种相关病毒引起的常见感染。在美国，它每年造成20,000-40,000人死亡。当新的流感感染人们时，感染可能会迅速传播到世界各地。这个全球传播称为大流行。在过去的100年中，发生了几种大流行。这些大流行病引起了许多人的感染和死亡。 1918年，近4000万人在流感大流行中死亡。一些新的人流感病毒来自鸟类流感病毒（也称为禽流感）。最近，一些鸟类流感病毒已感染了亚洲的人，并造成了许多死亡。这些流感菌株之一称为A/H5N1。人们担心这种新的菌株可能会导致大流行。疫苗可以预防感染和疾病。疫苗通过导致人体制造蛋白质称为抗体的蛋白质而起作用。有时需要超过1剂的疫苗，以便人体制造足够的抗体来抵抗感染。已经开发出疫苗以防止使用“常规”流感病毒感染。这些流感疫苗可以防止流感及其引起的健康问题。它们是由一部分被杀死的流感病毒制成的，并以“手臂射击”给出。我们正在使用针对鸟类流感病毒的杀死流感病毒疫苗A/H5N1进行这项研究。该疫苗被认为是研究的。它从未在人类中进行过测试。这种疫苗的方式与每年流感季节前每年给人的“常规”流感疫苗相同。在这项研究中，我们试图找出需要哪种疫苗的强度来产生“鸟流感”抗体的保护水平，这将帮助我们确定未来使用的正确剂量，如果需要的话。