GLUTEN-FREE DIET AND DIABETES

无麸质饮食和糖尿病

• 批准号: 7376948
• 负责人: DEBRA R COUNTS
• 金额: $ 0.45万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376948
• 关键词: GLUTEN; FREE; DIET; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with newly diagnosed Type 1 diabetes will be screened. Approximately 50 children will need to be screened to identify 12 children for randomization into the study groups, based on preliminary data (60 was requested through the HRPO to account for drop-out). 5 mL of blood by venipuncture will be drawn. Blood drawing will be done at the time of medically indicated blood work when possible, and children will be offered EMLA cream (topical anesthetic). Samples will be assayed by ELISA for zonulin. Children that have elevated zonulin levels, will be invited to participate. They will be randomized into controls (n=6) and intervention (GFD) (n=6). A mixed meal challenge test will be done to assess pancreatic reserve: Pediasure or Ensure is given po to a fasting subject, and then blood is drawn at baseline and in 90 min for C-peptide and zonulin measurement (20 ml total). HLA typing is done at this first test. This test will be repeated evey 3 months for one year or until C-peptide = 0 (no reserve). Immediately after randomization, the intervention group will be taught how to follow a gluten-free diet (GFD) and will be asked to follow this throughout the duration of the study. All subjects will have their diabetes managed according to the standard of care by their endocrinologist. Insulin requirements will also be tracked as a secondary measurement of pancreatic reserve.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。新诊断的 1 型糖尿病患者将接受筛查。根据初步数据，需要对大约 50 名儿童进行筛查，以确定 12 名儿童被随机分配到研究组（通过 HRPO 要求 60 名儿童来考虑辍学情况）。通过静脉穿刺抽取 5 mL 血液。如果可能的话，将在医学上指示的血液检查时进行抽血，并且将为儿童提供 EMLA 霜（表面麻醉剂）。将通过 ELISA 检测样品的连蛋白。连蛋白水平升高的儿童将被邀请参加。他们将被随机分为对照组 (n=6) 和干预组 (GFD) (n=6)。将进行混合膳食挑战测试来评估胰腺储备：将 Pediasure 或 Ensure 口服给禁食受试者，然后在基线和 90 分钟内抽血进行 C 肽和连蛋白测量（总共 20 ml）。 HLA 分型在第一次测试中完成。该测试将每 3 个月重复一次，持续一年或直到 C 肽 = 0（无储备）。随机分组后，干预组将立即被教导如何遵循无麸质饮食（GFD），并被要求在整个研究期间遵循这一点。所有受试者都将根据内分泌科医生的护理标准来管理糖尿病。胰岛素需求也将作为胰腺储备的辅助测量进行跟踪。