AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW:: SKIN SYMPATHETIC NERVE ACTIVITY

人类皮肤血流的年龄和控制:: 皮肤交感神经活动

• 批准号: 7378532
• 负责人: W. LARRY KENNEY
• 金额: $ 1.2万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378532
• 关键词: AGE; CONTROL; HUMAN; SKIN; BLOOD

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Research has shown that older people are less able to constrict cutaneous blood vessels in the cold. Since vasoconstriction increases the insulative capacity of the skin, impairment of this response causes increased heat loss in the cold and can make older people more susceptible to hypothermia. The primary site(s) of the age-related alteration in VC is unknown, but evidence points to efferent pathways (postganglionic sympathetic nerve activity, differential neurotransmitter effects, cutaneous vascular response) rather than primary age differences in hypothalamic integration. The specific aim of the present application examines a possible and plausible site in the efferent control pathway at which the age-related attenuation of reflex VC may occur. The proposed technique, quantitative skin microneurography, represents a state-of-the-art in vivo experimental approach. Until recently, this technique, or recent refinements thereof, were not available to test the stated hypotheses in human skin in vivo.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。研究表明，老年人在寒冷中限制皮肤血管的能力较低。由于血管收缩会增加皮肤的绝缘能力，因此这种反应的损害会导致寒冷的热量损失增加，并使老年人更容易受到低温的影响。 VC中与年龄相关的变化的主要部位尚不清楚，但证据表明，传出的途径（旋转后交感神经活性，差异神经递质效应，皮肤血管反应），而不是下丘脑整合的初级年龄差异。本申请的具体目的研究了可能发生与年龄相关的反射VC衰减的传出控制途径中可能的一个可能的位点。所提出的技术，定量皮肤微功能学，代表了体内实验方法的最新方法。直到最近，该技术或最近的改进还不能用于测试体内人类皮肤中所述的假设。