CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF

小儿透析患者导管相关感染：潜在作用

• 批准号: 7377123
• 负责人: HOWARD TRACHTMAN
• 金额: $ 0.08万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377123
• 关键词: CATHETER; RELATED; INFECTIONS; PEDIATRIC; DIALYSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with end stage renal disease (ESRD) who require dialysis through percutaneous access devices are susceptible to serious bacterial infections including catheter-related sepsis. There are considerable gaps in our understanding of the host factors that predispose patients on dialysis to develop catheter-related infections. Disturbances in monocyte/macrophage function have been documented in patients with ESRD. This project will test the hypothesis that abnormalities in plasma chemokine levels and cell-associated chemokine receptors result in diminished macrophage function, heightened risk of developing serious bacterial infections such as catheter-related sepsis, impaired response to treatment, and recurrent infection in pediatric patients on dialysis.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。需要通过经皮接入装置进行透析的患有终末期肾病（ESRD）的儿童和青少年容易受到严重的细菌感染，包括导管相关的败血症。我们对导致透析患者发生导管相关感染的宿主因素的理解存在相当大的差距。 ESRD 患者的单核细胞/巨噬细胞功能紊乱已有记录。该项目将检验以下假设：血浆趋化因子水平和细胞相关趋化因子受体的异常会导致巨噬细胞功能减弱、发生严重细菌感染（如导管相关败血症）的风险增加、对治疗的反应受损以及儿科患者的反复感染。透析。