CATHETER-RELATED INFECTIONS IN PEDIATRIC DIALYSIS PATIENTS: POTENTIAL ROLE OF

小儿透析患者导管相关感染：潜在作用

• 批准号: 7719251
• 负责人: HOWARD TRACHTMAN
• 金额: $ 0.55万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719251
• 关键词: Adolescent; Bacterial Infections; Catheters; Cells; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Devices; Dialysis patients; Dialysis procedure; End stage renal failure; Funding; Grant; Infection; Institution; Integration Host Factors; Patients; Physical Dialysis; Plasma; Recurrence; Research; Research Personnel; Resources; Risk; Role; Sepsis; Source; Testing; United States National Institutes of Health; catheter related infection; chemokine; chemokine receptor; macrophage; monocyte; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children and adolescents with end stage renal disease (ESRD) who require dialysis through percutaneous access devices are susceptible to serious bacterial infections including catheter-related sepsis. There are considerable gaps in our understanding of the host factors that predispose patients on dialysis to develop catheter-related infections. Disturbances in monocyte/macrophage function have been documented in patients with ESRD. This project will test the hypothesis that abnormalities in plasma chemokine levels and cell-associated chemokine receptors result in diminished macrophage function, heightened risk of developing serious bacterial infections such as catheter-related sepsis, impaired response to treatment, and recurrent infection in pediatric patients on dialysis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 通过经皮入口设备需要透析的终阶段肾脏疾病（ESRD）的儿童和青少年易受严重细​​菌感染（包括导管相关败血症）的严重细菌感染。 我们对宿主因素的理解有很大的差距，这些因素使患者易于透析，以发展与导管相关的感染。 ESRD患者已经记录了单核细胞/巨噬细胞功能的障碍。该项目将检验以下假设：血浆趋化因子水平和与细胞相关的趋化因子受体的异常导致巨噬细胞功能降低，增加了严重的细菌感染的风险，例如导管相关的脓毒症，例如对治疗的反应受损，以及对治疗的反应受损，以及在儿科患者中反复感染的感染。透析。