BRAINNATRIURETIC PEPTIDE (BNP) EXERCISE/REST RATIO

脑钠肽 (BNP) 运动/休息比

• 批准号: 7375927
• 负责人: DANIEL A DUPREZ
• 金额: $ 0.22万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375927
• 关键词: BRAINNATRIURETIC; PEPTIDE; BNP; EXERCISE; REST

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The heart produces a hormone, called BNP or Brain-Natriuretic Peptide. There is also pro-BNP, which is in fact the precursor of BNP. Pro-BNP and BNP are released when the stress on the wall of the heart is increased (for example, by exercise). We studied the release of these hormones as it relates to a supine bicycle exercise test with an increasing load in healthy subjects over a broad age range (18 to 65 years). The rationale to study them in the same subject was to sort out if either BNP or pro-BNP would be more sensitive in rising during exercise. We found that at peak exercise BNP levels are nearly double the levels found at rest. The concentration of pro-BNP was already at rest higher than BNP> This is logical because it is the precursor of BNP. The rise of pro-BNP was less pronounced that in case of BNP. Therefore, we would recommend further study of BNP during exercise in several conditions and not of proBNP, because this would not provide additional information. In the future, we will begin to look at BNP levels in patients with stiff walls of the heart, because this is in 50 percent in patients with heart failure, which is called ¿diastolic dysfunction¿. The heart is less able to relax after it has pumped out the blood through the aorta during its contraction. We hypothesize that BNP will increase more in patients with stiff walls of the heart (than in healthy controls) because there is more wall stress. If so, this could become an early marker to detect changes in stiffness of the heart, even before the development of any symptoms.

该主题项目是利用NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。心脏会产生一匹马，称为BNP或脑 - 催生肽。也有Pro-BNP，实际上是BNP的前体。当心脏壁上的压力增加（例如，通过运动）时，pro-BNP和BNP会释放。我们研究了这些骑兵的释放，因为它与仰卧的自行车运动测试有关，其健康受试者的负载在广泛的年龄范围内（18至65岁）。在同一受试者中研究它们的理由是弄清楚BNP或Pro-BNP是否在运动过程中会更敏感。我们发现，在峰值运动时，BNP的水平几乎是静止水平的两倍。 Pro-BNP的浓度已经比BNP高的静止状态>这是合乎逻辑的，因为它是BNP的前体。因此，我们建议在多种情况下而不是ProbNP的锻炼过程中进一步研究BNP，因为这不会提供其他信息。将来，我们将开始研究心脏衰竭患者50％的患者的BNP水平，因为这被称为“舒张功能障碍”。心脏在合同期间通过主动脉抽出血液后，心脏不太能够放松。我们假设患有硬壁的患者（而不是在健康对照组中），BNP会增加，因为壁应力更大。如果是这样，那么即使在任何符号的发展之前，这可能会成为检测心脏僵硬的变化的早期标记。