METHODS OF WEIGHT LOSS IN OVERWEIGHT PATIENTS WITH CORONARY HEART DISEASE

超重冠心病患者的减肥方法

• 批准号: 7378570
• 负责人: PHILIP A. ADES
• 金额: $ 102.46万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-09 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378570
• 关键词: cholesterol; exercise; heart; weight loss

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to study the effectiveness of a low calorie diet and two different types of exercise on weight control in overweight patients with Coronary Heart Disease (CHD). We will also closely measure the benefits of weight loss as it relates to measures that predict risk of further cardiac problems. These include cholesterol profiles, measures of glucose metabolism, body fat distribution and measures of blood clotting. Methods of weight loss and subsequent benefits in people with CHD have not been very well studied. We propose to study the effectiveness of: 1. A behaviorally-based weight loss program characterized by a daily calorie-intake goal and substantial behavioral and social support to attain dietary goals, and 2. Either of 2 types of supplementary exercise programs to assist with the weight loss intervention. These are characterized by variable amounts of exercise at our Cardiac Rehabilitation facility on the UVM campus, and home-walking. Strong evidence supports that exercise and improved coronary risk factors (cholesterol, blood pressure etc.) can significantly contribute to a reduction of fatal and non-fatal coronary events, an improved quality of life, and an increased life expectancy for people with coronary heart disease. In this study we will focus on the value of weight loss and exercise on decreasing future risk of heart problems.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是研究低卡路里饮食的有效性和在冠心病（CHD）超重患者体重控制方面的两种不同类型的运动。我们还将密切衡量体重减轻的益处，因为它与预测进一步心脏问题风险的措施有关。这些包括胆固醇谱，葡萄糖代谢的测量，体内脂肪分布和血液凝结的度量。体重减轻的方法和随后的冠心病患者的益处尚未得到很好的研究。我们建议研究：1。基于行为的减肥计划的有效性，其特征是每天卡路里的目标和实质性的行为和社会支持以实现饮食目标，而2则。两种补充运动计划中的任何一种以协助减肥干预。这些特征是在UVM校园的我们的心脏康复设施和家庭游行中进行的运动量变化。 有力的证据证明，运动和改善冠状动脉危险因素（胆固醇，血压等）可以显着促进致命和非致命冠状动脉事件的减少，改善的生活质量以及增加冠心病患者的预期寿命。在这项研究中，我们将重点关注体重减轻和运动的价值，降低心脏问题的未来风险。