EVALUATE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND SYMPATHETIC NERVOUS SYSTEM

评估下丘脑-垂体-肾上腺轴和交感神经系统

• 批准号: 7378840
• 负责人: SHERITA HILL GOLDEN
• 金额: $ 1.27万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378840
• 关键词: EVALUATE; HYPOTHALAMIC; PITUITARY; ADRENAL; AXIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Certain psychological factors, including depression, are risk factors for the development of diabetes and cardiovascular disease but the mechanism remains unclear. Neuroendocrine changes induced by these psychological factors, specifically activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS), might provide a unifying explanation. One limitation to assessing HPA axis activity in large population-based epidemiological studies as a risk factor for diabetes and cardiovascular disease has been the lack of a reliable, easy measurement to assess its function. The gold standard, a 24-hour urine collection for free cortisol, is cumbersome to perform in large-scale studies and is subject to variability. We hypothesize that salivary cortisol and adrenal volume are tightly correlated with HPA axis activity (as measured by 24-hour urine free cortisol) and therefore represent feasible approaches for assessment of HPA axis activity in large-scale cohort and epidemiological studies. The aims of this study are to 1) enroll 50 African-American women ages 18 to 45 years into an overnight GCRC study; 2) obtain measures of psychological traits, anthropometry, and biochemical parameters; and 3) to conduct statistical analyses to determine the following correlations: (a) 24-hour urine free cortisol with total, 8am, and 11 pm salivary cortisol and with adrenal volume; (b) insulin sensitivity and body-mass index with 24-hour urine free cortisol, adrenal volume, and salivary cortisol; and (c) psychological factors with 24-hour urine free cortisol, adrenal volume, and salivary cortisol. Identifying reliable, efficient measures of HPA axis activity will allow them to be incorporated into large, prospective cohort studies of cardiovascular disease and diabetes to determine if HPA axis hyperactivity is a risk factor for these two important diseases, which are significant public health burdens.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。某些心理因素（包括抑郁症）是糖尿病和心血管疾病发展的危险因素，但该机制尚不清楚。这些心理因素引起的神经内分泌变化，特别是对下丘脑 - 垂体 - 肾上腺（HPA）轴和交感神经系统（SNS）的激活，可能会提供统一的解释。评估大型基于人群的流行病学研究作为糖尿病和心血管疾病的危险因素的HPA轴活动的局限性是缺乏可靠，易于测量的评估来评估其功能。黄金标准是免费皮质醇的24小时尿液收集，在大规模研究中执行繁琐，并且会出现可变性。我们假设唾液皮质醇和肾上腺体积与HPA轴的活性密切相关（通过24小时无尿皮质醇测量），因此代表了评估大规模同学和流行病学研究中HPA轴活动的可行方法。这项研究的目的是1）入学50名18至45岁的非裔美国妇女参加了一夜GCRC研究； 2）获得心理特征，人体测量法和生化参数的度量； 3）进行统计分析以确定以下相关性：（a）24小时无尿液皮质醇，总计，上午8点和11点唾液皮质醇和肾上腺体积； （b）胰岛素敏感性和人体质量指数，含24小时的无尿皮质醇，肾上腺体积和唾液皮质醇； （c）具有24小时无尿皮质醇，肾上腺体积和唾液皮质醇的心理因素。确定可靠，有效的HPA轴活动措施将使它们被纳入对心血管疾病和糖尿病的大型前瞻性队列研究中，以确定HPA轴的多动症是否是这两种重要疾病的危险因素，这是重大的公共卫生负担。