ESOMEPRAZOLE TO TREAT GASTRO-ESOPHAGEAL REFLUX IN HEAD AND NECK CANCER PATIENTS

埃索美拉唑治疗头颈癌患者的胃食管反流

• 批准号: 7377043
• 负责人: DOUGLAS K TRASK
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377043
• 关键词: ESOMEPRAZOLE; TREAT; GASTRO; ESOPHAGEAL; REFLUX

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to measure acid reflux into the throat both before and after medical treatment in people who have had radiation therapy to their head and neck for the treatment of cancer. Many people who have received head and neck radiation therapy develop a dry mouth as a result of the radiation damage to their saliva glands. In addition to the discomfort associated with a dry mouth, the decrease in saliva may increase the severity of gastro-esophageal reflux disease (acid reflux). One-half of the people with acid reflux who participate will receive the study drug, Nexium, which is an approved and currently available medication to treat acid reflux. The other half will receive a placebo.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。这项研究的目的是测量因癌症治疗而对头部和颈部进行放射治疗的患者在接受治疗之前和之后喉咙中的胃酸反流。许多接受头颈部放射治疗的人由于唾液腺受到放射损伤而出现口干。除了与口干相关的不适之外，唾液减少还可能增加胃食管反流病（胃酸反流）的严重程度。参与的胃酸反流患者中有一半将接受研究药物 Nexium，这是一种已批准且目前可用的治疗胃酸反流的药物。另一半将接受安慰剂。