IS SMOOTH MUSCLE DYSFUNCTION AN EARLY EVENT IN ATHEROSCLEROSIS?

平滑肌功能障碍是动脉粥样硬化的早期事件吗？

• 批准号: 7377011
• 负责人: WILLIAM G HAYNES
• 金额: $ 0.53万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377011
• 关键词: SMOOTH; MUSCLE; DYSFUNCTION; EARLY; EVENT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The "fixed flow" concept is one that has been known for several decades. It states that following nitroglycerin, coronary blood flow and oxygen consumption were unchanged in patients with coronary artery disease. This is because ischemia is a powerful stimulus and much of the capacity of the vessel to dilate is utilized to maintain resting blood flow. Additionally, recent studies showed that the vasodilator response of conduit vessels to a nitric oxide donor nitroglycerin is impaired in subjects with coronary artery disease when compared to healthy controls. Other studies have suggested that only endothelium-dependent dilatation is impaired in atherosclerosis. We intend to compare endothelium-dependent and independent dilatation of conduit vessels in healthy subjects, smokers, and atherosclerotic patients. To date, no study has tested conduit vessel function using both an exogenous nitric oxide-donor dilator (such as nitroglycerin) and a non-nitric oxide mediated dilator (such as nifedipine). This will enable use to differentiate whether the dysfunction is in the smooth muscle (tunica media) layer of the vessel wall or due to nitric oxide inactivation. We hypothesize that atherosclerosis causes a predominant vascular smooth muscle dysfunction. As a secondary aim, we plan to investigate the vasodilator effect of beta 2-agonists (such as albuterol) as endothelium dependent dilators of conduit vessels in comparison with endothelium dependent flow-mediated dilatation.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。 “固定流”概念是几十年来闻名的。它指出，在冠状动脉疾病患者中，硝酸甘油，冠状动脉血流和氧气消耗没有改变。这是因为缺血是一种强大的刺激，并且使用血管扩张的大部分能力用于维持静止的血流。此外，最近的研究表明，与健康对照相比，导管血管对一氧化氮供体硝酸甘油对一氧化氮供体硝酸甘油的反应受到了损害。其他研究表明，动脉粥样硬化中只有内皮依赖性扩张受损。 我们打算比较健康受试者，吸烟者和动脉粥样硬化患者中导管容器的内皮依赖性和独立扩张。迄今为止，尚无研究使用外源性一氧化氮抑制剂（例如硝酸甘油）和非硝酸氧化物介导的扩张剂（例如硝酸化的扩张剂）（例如硝酸化的）测试导管血管功能。这将有助于区分容器壁的平滑肌（Tunica培养基）层还是由于一氧化氮的失活而导致的功能障碍。我们假设动脉粥样硬化会导致主要的血管平滑肌功能障碍。作为次要目的，我们计划研究与依赖于内皮的流量介导的扩张相比，β2-ponistist（例如沙丁胺醇）作为导管血管内皮扩张剂的血管扩张效应。