THE GENETIC EPIDEMIOLOGY OF INHERITED ABNORMALITIES OF PARTURITION

遗传性分娩异常的遗传流行病学

• 批准号: 7377216
• 负责人: Louis J Muglia
• 金额: $ 0.08万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377216
• 关键词: GENETIC; EPIDEMIOLOGY; INHERITED; ABNORMALITIES; PARTURITION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preterm delivery is a mojor public health problem with a significant impact on perinatal morbidity and mortality. Preterm infants currently constitute approximately 10% of live births and account for 50-70% of neonatal morbidity and mortality. This substantial public health problem has increased despite technological and medical advances over the past 30 years. Several different lines of evidence have suggested but not established a genetic contribution. The possibility of genes that cause or predispose to preterm labor holds tremendous protential for improving the management of preterm labor in the future. The overall goal of this protocol is to determine whether familial prematurity syndromes exist and if so to establish their genetic basis. We will evaluate mothers delivering preterm for the segregation of preterm delivery traits in their family and estimate the prevalence of inherited forms of preterm delivery. We will subsequently establish a linked epidemiologic and biologic repository that can be used for genomic scan and compare cases and controls to see if there are conditions associate with familial preterm delivery syndromes

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。早产是一个莫霍尔公共卫生问题，对围产期发病率和死亡率有重大影响。早产婴儿目前约占活生生的10％，占新生儿发病率和死亡率的50-70％。尽管过去30年中的技术和医疗进展，但这种实质性的公共卫生问题仍有增加。几种不同的证据表明但没有建立遗传贡献。引起或易于早产的基因的可能性具有巨大的蛋白质，可以改善未来的早产管理的管理。该方案的总体目标是确定是否存在家族性早产综合症，并确定其遗传基础。我们将评估母亲在其家庭中的早产特征分离的母亲，并估计遗传形式的早产形式的流行。随后，我们将建立一个链接的流行病学和生物学存储库，可用于基因组扫描并比较病例和对照，以查看是否存在与家族性早产综合征相关的条件