ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE

阿尔茨海默病神经影像计划

• 批准号: 7376649
• 负责人: JUDITH L HEIDEBRINK
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376649
• 关键词: Alzheimer' s disease; aging; biomarker; blood; brain; brain imaging /visualization /scanning; cerebrospinal fluid; conditioning; experimental designs; interview; lumbar puncture; magnetic resonance imaging; memory; positron emission tomography; thinking; urine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, it is difficult to diagnose Alzheime's disease (AD) and predict its progression with certainty. This multicenter study will look at the usefulness of brain imaging and other biological tests (biomarkers) in detecting AD and its progression. Participants will include older adults with either: 1) early AD, 2) normal memory and thinking, or 3) mild cognitive impairment (MCI), a condition that often represents a transitional state between normal aging and AD. Subjects will undergo interviews and examinations, cognitive testing, and brain magnetic resonance imaging (MRI) at approximately 6-month intervals for 2-3 years. Blood and urine samples will be collected. A subset of subjects will also undergo serial positron emission tomography (PET) brain imaging. Cerebrospinal fluid will be collected twice during the study from those subjects agreeing to have a lumbar puncture. Information and samples collected from participants at all sites will be stored centrally and made available to help researchers design future studies to treat or prevent Alzheimer's disease.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。目前，诊断阿尔茨海默病（AD）并准确预测其进展非常困难。这项多中心研究将探讨脑成像和其他生物测试（生物标志物）在检测 AD 及其进展方面的有用性。参与者将包括患有以下疾病的老年人：1) 早期 AD，2) 记忆和思维正常，或 3) 轻度认知障碍 (MCI)，这种情况通常代表正常衰老和 AD 之间的过渡状态。受试者将在 2-3 年内每隔约 6 个月接受一次访谈和检查、认知测试和脑磁共振成像 (MRI)。将收集血液和尿液样本。一部分受试者还将接受连续正电子发射断层扫描（PET）脑部成像。在研究期间，将从同意进行腰椎穿刺的受试者中采集两次脑脊液。从所有地点的参与者收集的信息和样本将集中存储，并可帮助研究人员设计未来的研究，以治疗或预防阿尔茨海默病。