PROXIMAL TUBULAR SODIUM REABSORPTION IN AFRICAN-AMERICANS AND WHITES: A TUBULOC

非裔美国人和白人的近端肾小管钠重吸收：TUBULOC

• 批准号: 7376644
• 负责人: ALAN B WEDER
• 金额: $ 3.99万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376644
• 关键词: kidney; sodium; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serious kidney disease resulting in kidney failure is much more common in African-Americans than Whites. High blood pressure and diabetes are the most important causes of kidney disease, but they alone do not explain the racial difference. We have proposed that differences in how kidneys handle salt (sodium) and water can affect the filtering units of the kidney and result in damage that ultimately causes kidney failure. This suggestion is based on our recent observation that African-Americans with normal blood pressure reclaim sodium at a critical site, known as the proximal tubule, more rapidly than Whites. In this proposal, we will characterize the regulation of proximal tubular sodium reabsorption and overall kidney sodium handling. We hypothesize that African-Americans will have measurable increases in factors that stimulate sodium reabsorption and decreases in mechanisms that inhibit reabsorption compared to Whites. The goal of these studies is to provide a better understanding of how tubular transport differences contribute to kidney failure, particularly in African-Americans. We anticipate that the proposed studies will lead to the development of a diagnostic test for identifying a predisposition to kidney failure and monitoring response to therapy.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。在非裔美国人中，导致肾衰竭的严重肾脏疾病比白人更为普遍。高血压和糖尿病是肾脏疾病的最重要原因，但仅它们并不能解释种族差异。我们提出，肾脏如何处理盐（钠）和水的差异会影响肾脏的过滤单元，并造成最终导致肾衰竭的损伤。这一建议是基于我们最近的观察结果，即在关键部位（称为近端小管，比白人）在关键部位收回钠的非裔美国人比白人更快。在此提案中，我们将表征近端管状钠重吸收和整体肾脏钠处理的调节。我们假设非洲裔美国人将在刺激钠重吸收并减少与白人相比抑制重吸收的机制的因素上增加可测量的增加。 这些研究的目的是更好地了解管状运输差异如何导致肾脏衰竭，尤其是在非裔美国人中。我们预计拟议的研究将导致开发诊断测试，以识别肾衰竭易感性和监测对治疗的反应。