NUTRITIONAL REGULATION OF ALBUMIN SYNTHESIS

白蛋白合成的营养调节

• 批准号: 7375338
• 负责人: MARGARET A. MCNURLAN
• 金额: $ 3.51万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375338
• 关键词: NUTRITIONAL; REGULATION; ALBUMIN; SYNTHESIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this study are to characterize better the nutritional factors regulating the acute response of albumin synthesis to feeding and to assess whether the response of albumin synthesis to feeding decreases with age. In particular we aim to investigate whether amino acids alone can stimulate albumin synthesis to the same extent as a complete meal and whether specific groups of amino acids (i.e. Essential, BCAA) or single amino acids are responsible for the stimulation of albumin synthesis rates. The acute effect of nutrients on albumin synthesis will be measured in both young and elderly individuals to investigate whether older people maintain a response to feeding and/or to specific dietary components. The results of this research may suggest patterns of eating, for example higher intakes of protein, that preserve the synthesis of albumin in the elderly allowing for the subsequent mobilization of these amino acids protected from oxidation by incorporation into albumin.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究的目的是更好地表征调节白蛋白合成对喂养的急性反应的营养因素，并评估白蛋白合成对喂养的反应是否随着年龄的增长而降低。特别是，我们旨在研究单独的氨基酸是否可以与完整餐的刺激白蛋白合成，以及特定的氨基酸组（即必需，BCAA）或单个氨基酸是否负责刺激白蛋白合成速率。营养物质对白蛋白合成的急性影响将在年轻人和老年人中测量，以调查老年人是否对喂养和/或对特定的饮食成分保持反应。这项研究的结果可能表明，饮食模式，例如蛋白质的摄入量更高，可以保留白蛋白在老年人中的合成，从而使这些氨基酸随后通过掺入白蛋白的氧化而动员。