GENETICS OF AFRICAN AMERICAN TYPE 2 DIABETES

非裔美国人 2 型糖尿病的遗传学

• 批准号: 7376706
• 负责人: MICHELE M SALE
• 金额: $ 28.85万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-17 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376706
• 关键词: diabetes risk; family; genes

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is estimated that 2.8 million African Americans have diabetes, which represents approximately 13% of all African Americans. On average, an African American individual is twice as likely to have diabetes as a Caucasian American of the same age. What are the reasons for this disparity, and how can the epidemic be reversed? There is compelling evidence for a significant genetic contribution to diabetes risk. Our approach has been to identify African American families with type 2 diabetes so that we may uncover the key inherited factors that contribute to disease susceptibility. With a scan of the entire human genome recently completed in over 250 African American families with diabetes, we have found one region that appears to harbor a diabetes-susceptibility gene. We are now in a position to hone in on this region of chromosome 6. We will first investigate known genes that may be involved in diabetes, but will likely need to explore the region in depth to locate and identify a novel diabetogenic gene. To evaluate the influence of these genes and this region on diabetes risk, we are currently recuiting additional African American patients with diabetes and African American individuals from the population to act as controls. The identification of genes contributing to diabetes in the African American population will be the first step toward developing prevention strategies and designing novel therapies.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。据估计，有280万非裔美国人患有糖尿病，约占所有非裔美国人的13％。平均而言，非洲裔美国人的糖尿病是同一年龄的高加索人的两倍。这种差异的原因是什么？如何逆转流行病？有令人信服的证据证明对糖尿病风险有重大遗传贡献。我们的方法是确定患有2型糖尿病的非洲裔美国家庭，以便我们可以发现导致疾病易感性的关键因素。由于最近在250多个非洲裔美国糖尿病家庭中完成了整个人类基因组的扫描，我们发现了一个似乎具有糖尿病敏感性基因的地区。现在，我们可以磨练6号染色体的区域。我们将首先研究可能参与糖尿病的已知基因，但可能需要深入探索该区域以定位和鉴定新的糖尿病基因。为了评估这些基因和该地区对糖尿病风险的影响，我们目前正在接受其他人群中的糖尿病和非裔美国人患者的其他非洲裔美国患者，以充当对照。鉴定有助于非裔美国人人口糖尿病的基因将是制定预防策略和设计新疗法的第一步。