GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 7003689
• 负责人: HARVEY R COLTEN
• 金额: $ 342.38万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-12-01 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7003689
• 关键词: GENERAL; CLINICAL; RESEARCH; CENTER

EXCEED THE SPACE PROVIDED. This application requests continued support for the General Clinical Research Center at Columbia University, which has operated continuously since 1970, and currently Supports research in Adult and pediatric Inpatient and Outpatient units at the Columbia Health Sciences Division campus of New York Presbyterian Hospital, and also inpatient and outpatient units at the St. Luke's-Roosevelt Hospital Center (SLRHC), three miles south of the primary GCRC. During the five-year period (Years 34-38) covered by this application, we propose to extend GCRC research coverage to the PICU, NICU and HIV clinics at Columbia. The Center provides facilities and staff for investigations of hospitalized and ambulatory patients that require skilled intensive nursing care, precise specimen collection and processing, rigorous dietary control, and expert laboratory and biostatistical support. Qualified faculty members of basic and clinical departments in the College of Physicians and Surgeons, the School of Public Health, and the School of Dental and Oral Surgery will study clinical problems that span the major fields of clinical investigation. The GCRC also fosters the training of young clinical investigators through existing K12 and K30 programs, and a variety of other training opportunities. We request support for 3,270 "A" days and 10,277 "A" visits annually at Columbia and SLRHC, 38.69 core FTE positions distributed among 48 individuals, a Core Laboratory, Bionutrition Research Unit, Informatics Core, and Biostatistical Consultation Core. This funding also supports the Research Advocate Program that places the protection of human subjects at the forefront of all research undertaken in the GCRC. Major research activities proposed in this grant are related to the following areas of human physiology and disease: (1) atherosclerotic cardiovascular disease, including coronary heart disease and stroke, (2) substance abuse, (3) obesity, nutrition, and energy metabolism, (4) neurodegenerative disorders, including Alzheimer's and Parkinson's disease, (5) diabetes melli_as, both type 1 and type 2, (6) lipid and lipoprotein metabolism, (7) disorders of bone-mineral metabolism, (8) neuro-imaging of psychiatric disorders, and (8) HIV infection and its complications. Emphasis has beer/placed on studies of ethnic minorities, who make up a large proportion of the population served by our community.

超过提供的空间。 该申请要求继续支持哥伦比亚大学一般临床研究中心， 自1970年以来一直在不断运作，目前支持成人和小儿住院的研究 纽约长老会医院哥伦比亚健康科学校区的门诊单位，也 在圣卢克绳索医院中心（SLRHC）的住院和门诊单元，在该医院以南三英里处 初级GCRC。在本申请涵盖的五年（34-38年）中，我们建议扩展 GCRC研究覆盖了哥伦比亚的PICU，NICU和HIV诊所。该中心提供设施和员工 为了对需要熟练的强化护理护理的住院和门诊患者进行调查，精确 标本收集和加工，严格的饮食控制以及专家实验室和生物统计支持。 学校医师和外科医生学院基本和临床系的合格教师 公共卫生和牙科和口腔外科学院将研究跨越主要领域的临床问题 临床研究。 GCRC还通过现有的K12培养了年轻临床研究人员的培训 和K30计划，以及其他各种培训机会。 我们要求支持3270“ A”天和10,277“ A”每年在哥伦比亚和SLRHC访问38.69 Core FTE 在48个人，一个核心实验室，Bionutrition研究部门，信息学核心和 生物统计咨询核心。这项资金还支持研究倡导者计划 保护人类受试者在GCRC中进行的所有研究的最前沿。主要的研究活动 本赠款中提出的与人类生理和疾病的以下领域有关：（1）动脉粥样硬化 心血管疾病，包括冠心病和中风，（2）药物滥用，（3）肥胖，营养和 能源代谢，（4）神经退行性疾病，包括阿尔茨海默氏病和帕金森氏病，（5）糖尿病 Melli_as，1型和2型，（6）脂质和脂蛋白代谢，（7）骨矿物质代谢的疾病，（8） 精神疾病的神经图像以及（8）HIV感染及其并发症。重点有啤酒/放在 对少数民族的研究，他们占我们社区服务的人口中很大一部分。

项目成果

Time course of moricizine's effect on signal-averaged and 12 lead electrocardiograms: insights into mechanism of action.

莫里西嗪对信号平均和 12 导联心电图的影响的时间进程：对作用机制的见解。

• DOI: 10.1016/0735-1097(91)90658-v
• 发表时间: 1991
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Wechsler,ME;Steinberg,JS;Giardina,EG
• 通讯作者: Giardina,EG

Preliminary studies on the effect of moderate physical activity on blood levels of glutathione.

适度体力活动对血液谷胱甘肽水平影响的初步研究。

• DOI: 10.1080/13547500500272663
• 发表时间: 2005
• 期刊: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
• 作者: Rundle,AG;Orjuela,M;Mooney,L;Tang,D;Kim,M;Calcagnotto,A;Richie,JP;Perera,F
• 通讯作者: Perera,F

Incidence of major cardiovascular events in black patients with normal myocardial stress perfusion study results.

心肌应激灌注正常的黑人患者主要心血管事件发生率的研究结果。

• DOI: 10.1067/mnc.2001.116497
• 发表时间: 2001
• 期刊: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
• 作者: Akinboboye,OO;Idris,O;Onwuanyi,A;Berekashvili,K;Bergmann,SR
• 通讯作者: Bergmann,SR

Partial loading of the left ventricle during mechanical assist device support is associated with improved myocardial function, blood flow and metabolism and increased exercise capacity.

机械辅助装置支持期间左心室的部分负荷与改善心肌功能、血流量和新陈代谢以及增加运动能力有关。

• DOI: 10.1016/s1053-2498(01)00392-8
• 发表时间: 2002
• 期刊: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• 作者: Maybaum,Simon;Epstein,Shilpi;Beniaminovitz,Ainat;DiTullio,Marco;Oz,Mehmet;Bergmann,StevenR;Mancini,Donna
• 通讯作者: Mancini,Donna

Breast-feeding and maternal cardiovascular function.

母乳喂养和母亲心血管功能。

• DOI: 10.1111/1469-8986.3860988
• 发表时间: 2001
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Mezzacappa,ES;Kelsey,RM;Myers,MM;Katkin,ES
• 通讯作者: Katkin,ES