THE COMPARISON OF PLACENTAL AND UMBILICAL NUCLEATED RED BLOOD CELL COUNT

胎盘和脐带有核红细胞计数的比较

• 批准号: 7376109
• 负责人: Michael Glenn Ross
• 金额: $ 0.04万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376109
• 关键词: COMPARISON; PLACENTAL; UMBILICAL; NUCLEATED; RED

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will attempt to quantify the presence and number of a certain type of blood cell (nucleated red blood cell; nRBC) in the placenta and umbilical cord blood. The placenta is an organ used by the mother for oxygenation and nutrition of the fetus. This organ is no longer needed by the mother or the fetus after birth and is generally discarded or sent to pathology. The umbilical cord is attached to this organ and carries blood to and from the fetus. The umbilical cord likewise is discarded after birth. This project will involve collection of the placenta and umbilical cord blood of 100 mothers who deliver at Harbor-UCLA Medical Center (HUMC). Following delivery, umbilical cord artery and vein specimens will be obtained for pH and blood gas analysis and nRBC count. Placental tissue will be examined by the HUMC Pathology Dept (Dr. L. McPhaul) for nRBC count. During the first 30 minutes of newborn life, a capillary heel stick blood sample will be obtained for pH, blood gas and nRBC. We will assess the relation of umbilical arterial blood, and newborn capillary heel blood and placental nRBC count. We will futher assess the correlation of umbilical and newborn pH and base excess values to the level of nRBC.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。该项目将尝试量化胎盘和脐带血液中某种类型的血细胞（核定红细胞； NRBC）的存在和数量。胎盘是母亲使用的器官，用于胎儿的氧合和营养。出生后，母亲或胎儿不再需要这种器官，通常被丢弃或送入病理学。脐带附着在该器官上，并从胎儿带走血液。脐带同样在出生后也被丢弃。该项目将涉及收集在Harbour-UCLA医疗中心（HUMC）的100位母亲的胎盘和脐带血。分娩后，将获得脐带动脉和静脉标本以进行pH和血液分析和NRBC计数。 NRBC计数将通过HUMC病理部（L. McPhaul博士）检查胎盘组织。在新生儿的最初30分钟内，将获得用于pH，血液和NRBC的毛细管脚跟棒血样。 我们将评估脐动脉血和新生儿毛细管血液和胎盘NRBC计数的关系。我们将评估脐带和新生儿pH以及基本过剩值与NRBC水平的相关性。