THE SIGNIFICANCE OF FUNGURIA IN HOSPITALIZED PATIENTS

真菌感染对住院患者的意义

• 批准号: 7376044
• 负责人: LOREN G. MILLER
• 金额: $ 0.37万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376044
• 关键词: SIGNIFICANCE; FUNGURIA; HOSPITALIZED; PATIENTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The incidence of fungal urinary tract infections, largely caused by Candida species, is rapidly increasing in hospitalized patients. In just a decade, the proportion of fungal urinary isolates from medical intensive care units has increased from 22% to 39%. The significance of fungi isolated from urinary tract remains a subject of considerable debate. We will perform a prospective study of hospitalized patients with funguria over a 12-month period. Patients with funguria will be followed longitudinally for persistence of infection and complications of funguria. We will also characterize similar-sized cohort of control patients known not to have funguria for comparison. These two populations will be used to create a large data set from which models can be developed to answer the questions of whether funguria is independently associated with fungemia, mortality, and morbidity associated with increased resource use. To comprehensively understand potential complications of funguria, we plan to follow long-term outcomes of patients with funguria up to 1 year after hospital discharge. We will use molecular-typing methods to investigate strain relatedness between blood and urine fungal isolates in patients who have both funguria and fungemia. This molecular typing will determine if fungi isolated from urine are associated with a serious systemic infection or represent a synchronous, unrelated lower tract process. From these comprehensive studies of funguria, we will develop focused strategies for the management of funguria that are intended to result in both cost savings and a reduction in the incidence of nosocomial infections caused by azole-resistant fungi.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。住院患者的真菌尿路感染的发生率很大程度上是由念珠菌物种引起的。在短短的十年中，医疗重症监护病房的真菌尿液分离株的比例已从22％增加到39％。从尿路中分离出的真菌的意义仍然是一个相当大的争论的主题。我们将在12个月内对住院的真菌患者进行前瞻性研究。造真菌患者将纵向遵循感染和并发症的持续性。我们还将表征相似大小的对照患者队列，已知不具有真菌进行比较。这两个人群将用于创建一个大型数据集，可以从中开发模型，以回答造真菌是否与真菌，死亡率和与资源增加相关的发病率独立相关的问题。为了全面了解真菌的潜在并发症，我们计划跟踪出院后长达1年的真菌患者的长期结局。我们将使用分子型方法来研究患有真菌和真菌性的患者血液和尿液真菌分离株之间的菌株相关性。该分子键入将确定从尿液中分离出来的真菌是否与严重的全身感染相关或代表同步的，不相关的下段过程。从这些对真菌的全面研究中，我们将制定针对真菌管理的集中策略，这些策略旨在节省成本，并降低由抗硫唑的真菌引起的医院感染发生率。