STUDY TO DETERMINE THE SITE OF INTESTINAL CYSTEAMINE ABSORPTION

确定肠道半胱胺吸收部位的研究

• 批准号: 7374185
• 负责人: RANJAN DOHIL
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374185
• 关键词: birth

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine the effect of cysteamine on leukocyte cystine, blood cysteamine and gastrin levels when administered directly into the stomach, small intestine or colon. Learn if hypergastrinemia and gastric acid-hypersecretion differ based on the site of cysteamine delivery. Decide whether it might be advantageous to develop a slow-release cysteamine delivery system or whether there would be a significant advantage to simply delivering the drug to a different intestinal site.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。当直接在胃中，小肠或结肠癌中施用时，确定氰氨酸对白细胞胱氨酸，血清cysteamine和胃蛋白水平的影响。了解过高gastrinemia和胃酸 - 甲状腺肿是否根据cysteamine递送部位而有所不同。确定开发缓慢释放的cysteamine递送系统，还是简单地将药物输送到其他肠部位是否有很大的优势。