LOOK AHEAD: ACTION FOR HEALTH IN DIABETES

展望未来：糖尿病健康行动

• 批准号: 7378155
• 负责人: STEVEN M. HAFFNER
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378155
• 关键词: LOOK; AHEAD; ACTION; HEALTH; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: The primary objective of the Look AHEAD project is to examine, in overweight volunteers with type 2 diabetes, the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. RESEARCH PLAN: This program is compared to a controlled condition involving a program of diabetes support and education. The primary basis for the comparison is the incidence of serious cardiovascular events. Other outcomes, including cardiovascular disease risk factors, diabetes related metabolic factors and complications, and the cost-effectiveness of the intensive intervention are also studied. Study population will be approximately 5,000 volunteers with type 2 diabetes who are 45-75 years old and overweight (body mass index greater than or equal to 25). METHODS: Eligible volunteers are randomly assigned to an intensive lifestyle intervention or to diabetes support and education. Treatment assignments are unmasked. The lifestyle intervention is implemented with individual supervised and group sessions and is aimed at achieving and maintaining at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity. The primary outcome is the aggregate occurrence of severe cardiovascular events including fatal and non-fatal myocardial infarctions, stroke, and cardiovascular deaths over a planned follow-up period of up to 11.5 years. The study is a multi-center, two-armed randomized, controlled clinical trial. With 5,000, the study has a 90% probability of detecting an 18% difference in major cardiovascular disease events between the intervention groups.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。目的：未来外观项目的主要目标是在患有2型糖尿病的超重志愿者中检查密集的生活方式干预计划的长期影响，旨在通过减少热量摄入和增加体育锻炼来实现和维持体重减轻。 研究计划：该计划与涉及糖尿病支持和教育计划的受控状况进行了比较。比较的主要基础是严重心血管事件的发生率。还研究了其他结果，包括心血管疾病危险因素，相关的代谢因素和并发症以及强化干预的成本效益。研究人群将是45-75岁且超重的2型糖尿病志愿者（体重指数大于或等于25）。 方法：符合条件的志愿者被随机分配到密集的生活方式干预措施或糖尿病支持和教育。治疗任务是揭露的。生活方式干预是通过个人监督和小组会议实施的，旨在实现和保持至少7％的体重减少7％，每周175分钟的体育锻炼。主要结果是在计划的随访期内，发生了严重的心血管事件，包括致命和非致命心肌梗死，中风和心血管死亡，最高11。5年。该研究是一项多中心，两臂随机，对照临床试验。该研究具有5,000个，有90％的概率是检测干预组之间主要心血管疾病事件的差异18％。