IRAS FAMILY STUDY EXAMINATION-2

IRAS 家庭研究考试-2

• 批准号: 7378156
• 负责人: STEVEN M. HAFFNER
• 金额: $ 13.16万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378156
• 关键词: IRAS; FAMILY; STUDY; EXAMINATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: Initiate positional cloning of genes contributing to adiposity and glucose homeostasis, the primary phenotypes evaluated in the IRAS Family Study baseline examination. RESEARCH PLAN: The primary goals of this component, the re-examination of the IRAS Family Study cohort, are to obtain new biological insights into the genetic basis of adiposity and glucose homeostasis by collection of phenotypes that add depth to our baseline data and to obtain behavioral data for interpretation and analysis of the primary phenotypes. The collection of the baseline data provided important cross-sectional genetic and epidemiologic insights; however, to enhance the biological interpretation of the study findings, particularly with respect to change in adiposity and glucose homeostasis measures as they related to genetic factors, adipocytokines and environmental modifiers, targeted follow-up data collection is required. METHODS: All family members who participated in the baseline phenotyping portion of the IRAS Family Study clinical examination between October 1999 and March 2002 will be contacted to participate in this follow-up examination. The follow-up examination will occur approximately 5 years after the initial examination. Participation in the follow-up exam should be enhanced by our annual contact with our participants. Participants will report to their original clinical center for a two-hour examination that includes the measures described below and in Appendix 1. After informed consent, trained technicians will obtain fasting blood and urine samples, will perform anthroptometry and will measure resting blood pressure. Interviews will be administered by trained interviewers. Whole body DXA scans will be performed in the clinic. The abdominal CT scan will be performed at an off-site location following the same protocol as the baseline examination. For participants unwilling or unable to attend a follow-up clinic examination, self-report of weight and diabetes status will be obtained. CLINICAL RELEVANCE: The Mammalian Genotyping Service (MGS) has completed a genome scan of the DNA samples collected from the family members (approximately 2000 individuals). Linkage analyses have identified genomic regions related to adiposity and glucose homeostasis phenotypes. The linkage results have motivated follow-up by molecular genetic approaches.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。目的：启动有助于肥胖和葡萄糖稳态的基因的位置克隆，这是IRAS家族研究基线检查中评估的主要表型。 研究计划：该组成部分的主要目标，即IRAS家族研究队列的重新检查，是通过收集在我们的基线数据中增加深度并获得的表型来获得对肥胖和葡萄糖稳态的遗传基础的新生物学见解。用于解释和分析主要表型的行为数据。基线数据的收集提供了重要的横断面遗传和流行病学见解。但是，为了增强研究发现的生物学解释，特别是在肥胖和葡萄糖稳态度量的变化方面，由于它们与遗传因素，脂肪细胞因子和环境修饰符相关，因此需要有针对性的随访数据收集。 方法：在1999年10月至2002年3月之间，所有参加IRAS家庭研究临床检查基线表型部分的家庭成员将与参与此后续检查。后续检查将在初次检查后大约5年进行。我们与参与者的年度接触应加强后续考试。参与者将向其原始的临床中心报告两个小时的检查，其中包括以下和附录1中所述的措施。在知情同意后，训练有素的技术人员将获得空腹血液和尿液样本，将执行人为仪，并将测量静止血压。访谈将由训练有素的访调员管理。全身DXA扫描将在诊所进行。腹部CT扫描将按照与基线检查相同的协议在异地位置进行。对于不愿或无法参加后续诊所检查的参与者，将获得体重和糖尿病状况的自我报告。 临床相关性：哺乳动物基因分型服务（MGS）已完成了从家庭成员收集的DNA样本（约2000个个体）的基因组扫描。连锁分析已经确定了与肥胖和葡萄糖稳态表型有关的基因组区域。连接结果通过分子遗传方法促进了随访。