Feedback Control of Respiration Induced Tumor Motion with a Treatment Couch

使用治疗床对呼吸引起的肿瘤运动进行反馈控制

• 批准号: 7318613
• 负责人: WARREN D D'SOUZA
• 金额: $ 29.84万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318613
• 关键词: Abdomen; Accounting; Algorithms; Biological; Biomedical Engineering; Breathing; Cine Magnetic Resonance Imaging; Clinical; Clinical Trials; Computer software; Condition; Conformal Radiotherapy; Development; Discipline; Disease regression; Dose; Effectiveness; Ensure; Evaluation; Feedback; Financial compensation; Funding; Goals; Hot Spot; Image; Individual; Intensity-Modulated Radiotherapy; Lead; Least-Squares Analysis; Length; Linear Accelerator Radiotherapy Systems; Lung; Magnetic Resonance Imaging; Malignant neoplasm of abdomen; Medical; Methods; Modeling; Morphologic artifacts; Motion; Normal tissue morphology; Numbers; Organ; Outcome; Patients; Pattern; Performance; Physics; Positioning Attribute; Radiation; Radiation therapy; Request for Proposals; Research; Research Personnel; Research Project Grants; Resources; Respiration; Risk; Safety; Shapes; Signal Transduction; Site; Skin; Solutions; System; Technology; Testing; Time; Tissues; Toxic effect; Tumor Volume; X-Ray Computed Tomography; college; computerized data processing; design; design and construction; image processing; improved; irradiation; medical schools; novel; optical imaging; programs; sensor; technique development; time use; treatment duration; treatment planning; tumor

DESCRIPTION (provided by applicant): Respiration induced tumor motion leads to inaccuracies in the planning and delivery of radiation therapy treatments. This is particularly important for highly conformal therapies such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT). Conventional solutions included adding a 'safety margin" around the tumor which can often result in unnecessary irradiation of normal tissue thereby increasing normal tissue toxicity. Current commercially available methods with linear accelerators include breath-holds and gating during radiation delivery. The former is not tolerated well by patients while the later increases treatment delivery time, thereby increasing the risk of spurious patient motion and even reducing the biological effectiveness of the delivered radiation. We propose to develop a novel tumor motion compensation system using a treatment couch that will ensure accurate delivery of radiation treatment without increasing discomfort or treatment time and without decreasing the biological effectiveness. The goal of this proposal is to develop a real-time motion-synchronized treatment couch system using feedback control. The specific aims of this proposal are to 1) use cine MR to dynamically image the tumor and an infrared camera to image skin markers simultaneously during normal respiration, 2) develop an inferential model that will correlate the position of the skin markers with the tumor position using partial-least squares (PLS) regression, 3) design and test a treatment couch and control system that will compensate for respiration induced motion using feedback control, 4) use autoregressive modeling to predict the tumor position ahead of time in order to improve the performance of the feedback control system by overcoming the dead time in the system and adaptive filtering to identify anamolous tumor positions. The results from our proposal have the potential to significantly impact radiation therapy of lung and upper abdominal cancers. The proposed research effort will lead to the development of a novel motion management framework using a real-time motion-synchronized treatment couch. Its eventual implementation in clinical practice will lead to reduced normal tissue toxicity through the use of smaller tumor margins and accurate tumor motion compensation. This will enable more widespread use of highly conformal treatments such as intensity- modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) in a reliable manner.

描述（由申请人提供）：呼吸引起的肿瘤运动导致辐射治疗的计划和交付不准确。这对于高度共形疗法（例如强度调节的放射疗法（IMRT）和立体定向身体放射疗法（SBRT））尤其重要。常规解决方案包括在肿瘤周围增加“安全边缘”，这通常会导致不必要的正常组织照射，从而增加正常的组织毒性，从而增加正常的组织毒性。当前使用线性加速器的市售方法包括呼吸呼吸和辐射过程中的辐射过程中，前者并不能使患者良好地耐受效率，从而增加了治疗时间，从而使患者的效率增加了，甚至增加了运动的效率，甚至可以增加效率，甚至增加了动作的效果辐射。我们建议使用治疗沙发开发新的肿瘤运动补偿系统，以确保辐射治疗不增加不适或处理时间，而无需降低生物学效果。 normal respiration, 2) develop an inferential model that will correlate the position of the skin markers with the tumor position using partial-least squares (PLS) regression, 3) design and test a treatment couch and control system that will compensate for respiration induced motion using feedback control, 4) use autoregressive modeling to predict the tumor position ahead of time in order to improve the performance of the feedback control system by overcoming the dead time in the system and adaptive filtering鉴定肿瘤位置。我们提案的结果有可能显着影响肺和上腹部癌的放射治疗。拟议的研究工作将导致使用实时运动同步治疗沙发的新运动管理框架的发展。它在临床实践中的最终实施将通过使用较小的肿瘤边缘和准确的肿瘤运动补偿来导致正常组织毒性降低。这将以可靠的方式更广泛地广泛使用高度共形治疗，例如强度调制辐射疗法（IMRT）和立体定向的身体放射治疗（SBRT）。