THE ROLE OF GHRELIN IN SOMATOPAUSE

生长素释放肽在躯体停经中的作用

• 批准号: 7376880
• 负责人: ELENI V DIMARAKI
• 金额: $ 2.28万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376880
• 关键词: ROLE; GHRELIN; SOMATOPAUSE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aging is associated with decreased Growth Hormone (GH) secretion, known as somatopause. While in older men this may be in part secondary to diminished secretion of Growth Hormone Releasing Hormone (GHRH), this is not true for women. Ghrelin, a recently discovered gastric peptide, strongly stimulates GH release and its levels are three times higher in young women at the high estrogen phase of the menstrual cycle than in young men. We will examine whether somatopause is associated with a decrease in ghrelin secretion and how the estrogen milieu affects ghrelin secretion. Forty-eight healthy individuals in four age and gender specific groups will be studied. Men will be admitted to the General Clinic Research Center once and women twice during artificially induced "estrogen rich" and "poor" periods. During each admission, blood will be drawn for plasma levels of GH and ghrelin for twenty-four hours. After this period, an intravenous dose of GHRP-2, a synthetic substance similar to ghrelin, will be given and GH will be measured to help distinguish whether changes in ghrelin sensitivity contribute to somatopause. Finally, an IVGTT, a test involving intravenous injection of glucose and insulin to assess sensitivity to insulin, will be performed.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。衰老与生长激素 (GH) 分泌减少有关，称为躯体更年期。虽然对于老年男性来说，这可能部分是由于生长激素释放激素 (GHRH) 分泌减少所致，但对于女性来说却并非如此。生长素释放肽是最近发现的一种胃肽，可强烈刺激生长激素释放，其水平在月经周期雌激素高期的年轻女性中是年轻男性的三倍。我们将研究躯体更年期是否与生长素释放肽分泌减少有关以及雌激素环境如何影响生长素释放肽分泌。将研究四个年龄和性别特定组的 48 名健康个体。在人工诱导的“雌激素丰富”和“雌激素缺乏”时期，男性将被送往普通临床研究中心一次，女性将被送往普通临床研究中心两次。每次入院期间，将抽血测定 24 小时内 GH 和生长素释放肽的血浆水平。在此期间之后，将静脉注射 GHRP-2（一种类似于生长素释放肽的合成物质），并测量 GH，以帮助区分生长素释放肽敏感性的变化是否会导致躯体更年期。最后，将进行 IVGTT，这是一项涉及静脉注射葡萄糖和胰岛素以评估对胰岛素敏感性的测试。