THE ROLE OF GHRELIN IN SOMATOPAUSE

生长素释放肽在躯体停经中的作用

• 批准号: 7376880
• 负责人: ELENI V DIMARAKI
• 金额: $ 2.28万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376880
• 关键词: ROLE; GHRELIN; SOMATOPAUSE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aging is associated with decreased Growth Hormone (GH) secretion, known as somatopause. While in older men this may be in part secondary to diminished secretion of Growth Hormone Releasing Hormone (GHRH), this is not true for women. Ghrelin, a recently discovered gastric peptide, strongly stimulates GH release and its levels are three times higher in young women at the high estrogen phase of the menstrual cycle than in young men. We will examine whether somatopause is associated with a decrease in ghrelin secretion and how the estrogen milieu affects ghrelin secretion. Forty-eight healthy individuals in four age and gender specific groups will be studied. Men will be admitted to the General Clinic Research Center once and women twice during artificially induced "estrogen rich" and "poor" periods. During each admission, blood will be drawn for plasma levels of GH and ghrelin for twenty-four hours. After this period, an intravenous dose of GHRP-2, a synthetic substance similar to ghrelin, will be given and GH will be measured to help distinguish whether changes in ghrelin sensitivity contribute to somatopause. Finally, an IVGTT, a test involving intravenous injection of glucose and insulin to assess sensitivity to insulin, will be performed.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。衰老与生长激素（GH）分泌的降低有关，称为体系。尽管在老年男性中，这可能部分是因为生长激素释放激素（GHRH）的分泌减少，但对于女性来说并不是这样。 Ghrelin是一种最近发现的胃肽，在月经周期的高雌激素期的年轻女性中强烈刺激GH的释放，其水平高三倍。我们将检查体囊性是否与生长素素分泌的降低以及雌激素环境如何影响生长素释放蛋白分泌有关。将研究四十八个年龄和性别特定组的健康个体。在人为诱发的“雌激素富含”和“差”时期，男性将被送入一般诊所研究中心，两次女性被录取。在每次入院期间，将吸收血浆GH和GHRELIN的血液二十四小时。在此之后，将给出静脉注射GHRP-2的静脉剂量，即类似于生长素蛋白的合成物质，并将测量GH，以帮助区分生长素素敏感性的变化是否有助于体层。最后，将进行一项IVGTT，该测试将进行涉及静脉注射葡萄糖和胰岛素以评估胰岛素敏感性的测试。