A MOLECULAR FOUNDATION FOR THE TREATMENT OF ARSENIC POISONING IN BANGLADESH

孟加拉国治疗砷中毒的分子基础

• 批准号: 7370629
• 负责人: GRAHAM N GEORGE
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7370629
• 关键词: MOLECULAR; FOUNDATION; TREATMENT; ARSENIC; POISONING

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In what has been called the world¿¿s worst mass poisoning, between 35 and 70 million people are affected by chronic low-level arsenic poisoning in Bangladesh and surrounding areas. We have previously suggested that this poisoning is not directly due to the toxic effects of arsenic, but is instead primarily due to arsenic-induced selenium deficiency. We plan to build on our earlier work to provide a molecular foundation for the treatment of chronic low-level arsenic poisoning in Bangladesh and other affected areas. X-ray absorption spectroscopy (XAS) holds the key to these discoveries.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一，该子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 机构中得到体现。列出的是中心，它不一定是所谓的世界中的调查员机构。 ¿最严重的大规模中毒事件是，孟加拉国及周边地区有 35 至 7000 万人受到慢性低浓度砷中毒的影响。我们之前曾指出，这种中毒并非直接由砷的毒性作用造成，而主要是由于砷的毒性作用造成的。我们计划在早期工作的基础上为孟加拉国和其他受影响地区的慢性低水平砷中毒的治疗提供分子基础。 （XAS）掌握着这些发现的关键。