Qigong Therapy for Treating Cocaine Addiction

气功疗法治疗可卡因成瘾

• 批准号: 7034483
• 负责人: DAVID A SMELSON
• 金额: $ 18.98万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7034483
• 关键词: alternative medicine; anxiety; behavioral /social science research tag; behavioral medicine; clinical research; clinical trials; cocaine; craving; cues; data collection methodology /evaluation; depression; drug /alcohol abstinence; drug abuse therapy; drug withdrawal; exercise; human subject; human therapy evaluation; interview; meditation; outcomes research; patient care management; patient oriented research; questionnaires; substance abuse related behavior; urinalysis

DESCRIPTION (provided by applicant): This revised R21 grant application (1R21AT001350-01A1) was previously submitted in October, 2003, to perform a randomized double-blind placebo-controlled trial to investigate external Qigong therapy (EQT) in reducing cue-elicited craving and improving treatment outcome in withdrawn cocaine dependent patients. The specific aims of the study include: (1) Examining the efficacy of EQT for reducing cue-elicited cocaine craving in acutely abstinent cocaine dependent subjects; (2) Investigating the effect of EQT on reducing symptoms of anxiety and depression associated with acute withdrawal; (3) Investigating the effect of EQT on reducing substance use and the incidence of addiction-related problems; and (4) Testing whether the benefits of EQT are independent of the perceived credibility of EQT and the expectancy one has of experiencing positive treatment outcomes. These aims will be achieved through a trial with 98 cocaine dependent subjects who will be randomly assigned to either a Qigong treated group or a Sham treated control group. Qigong treatment consists of "Qi emission" by the Qigong Master toward the head area for a total of six 10-minute sessions over 2 weeks. EQT effectiveness in reducing craving will be determined using a cue-elicited craving paradigm. This involves a set of highly standardized and safe procedures for inducing craving in a controlled laboratory setting by exposing subjects to cocaine-related and neutral non-drug related cues. The present researchers have employed this methodology in clinical trials to screen anti-craving medications for cocaine addiction for the past 8 years. In addition to the two-week laboratory model, this study will also examine the efficacy of Qigong for reducing anxiety and depression associated with acute withdrawal, increasing sobriety, and improving substance use and related problems identified on the Addiction Severity Index. Finally, we will examine whether the subject's belief in treatment has an effect on treatment outcomes. The pilot data collected through this R21 grant will serve as a basis for future R01 applications to examine Qigong efficacy in improving craving and treatment outcome for cocaine addiction.

说明（由申请人提供）：这份修订后的 R21 拨款申请 (1R21AT001350-01A1) 于 2003 年 10 月提交，旨在进行一项随机双盲安慰剂对照试验，以研究外部气功疗法 (EQT) 在减少提示引起的渴望方面的作用并改善戒断可卡因依赖患者的治疗结果。该研究的具体目的包括：（1）检查 EQT 在减少急性戒断可卡因依赖受试者中线索引发的可卡因渴望方面的功效； (2) 研究EQT对减轻急性戒断相关焦虑和抑郁症状的作用； (3) 研究 EQT 对减少物质使用和成瘾相关问题发生率的效果； (4) 测试 EQT 的益处是否独立于 EQT 的可信度以及人们对积极治疗结果的期望。这些目标将通过对 98 名可卡因依赖者进行试验来实现，这些受试者将被随机分配到气功治疗组或假手术治疗对照组。气功治疗包括由气功师对头部区域进行“气发射”，为期两周，总共六次，每次 10 分钟。 EQT 在减少渴望方面的有效性将使用提示引发的渴望范式来确定。这涉及一套高度标准化和安全的程序，通过让受试者接触可卡因相关和中性的非药物相关线索，在受控实验室环境中诱导渴望。过去 8 年来，研究人员一直在临床试验中采用这种方法来筛选可卡因成瘾的抗渴药物。除了为期两周的实验室模型外，这项研究还将检验气功在减少与急性戒断相关的焦虑和抑郁、提高清醒度、改善物质使用和成瘾严重程度指数上确定的相关问题方面的功效。最后，我们将检查受试者对治疗的信念是否对治疗结果有影响。通过 R21 拨款收集的试点数据将作为未来 R01 申请的基础，以检查气功在改善可卡因成瘾的渴望和治疗结果方面的功效。