Cue-Elicited Craving /Genetics in Relapse in Cocaine Use

可卡因吸食复发中的提示引发的渴望/遗传学

• 批准号: 7011912
• 负责人: DAVID A SMELSON
• 金额: $ 7.78万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-29 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7011912
• 关键词: African American; behavioral /social science research tag; behavioral genetics; clinical research; cocaine; craving; cues; dopamine receptor; drug addiction; endorphins; genetic polymorphism; genetic screening; human subject; interview; longitudinal human study; male; neuropeptide receptor; neurotransmitter receptor; polymerase chain reaction; receptor expression; relapse /recurrence; single nucleotide polymorphism; substance abuse related behavior; urinalysis

DESCRIPTION (provided by applicant): This R03 grant application, submitted in response to RFA-DA-05-004 "Lapse and Relapse to Drug Abuse and Other Chronic Conditions," proposes an interdisciplinary project with collaborations between clinical and basic scientists to examine the roles of cue-reactivity and genetic polymorphisms as possible etiological mechanisms in the relapse to cocaine use. This represents one of the few studies of relapse in human populations to combine laboratory-based measures with community-based follow-up to understand the biological and behavioral foundations of relapse to cocaine. The specific aims of the study are to: (1) examine whether drug-free cocaine dependent cue-reactive individuals are more likely to relapse than nonreactive individuals; (2) determine whether cue-elicited craving responses are significantly different in cocaine dependent individuals with polymorphisms in candidate genes in the dopamine and beta-endorphin pathways compared to individuals without the polymorphisms; and (3) determine whether individuals with genetic polymorphisms are more likely to relapse with cocaine than those without the genetic polymorphisms. This proposed project will be an "add-on" to an existing five-year Center for Substance Abuse Treatment grant (CSAT) awarded to Drs. Smelson and Kline and funded through 2009. The CSAT grant targets 550 individuals with a substance abuse disorder entering treatment at the Department of Veterans Affairs New Jersey Health Care System (VANJ). This proposed R03 will recruit a subgroup of 105 African American males with a confirmed diagnosis of cocaine dependence who are enrolled in the CSAT project. Those recruited into this R03 study will undergo a baseline assessment battery, cue-exposure procedure, blood withdrawal for genetic analysis, and urine toxicology screening. The subjects will be reassessed with the Addiction Severity Index and urine toxicology screen at six months post-baseline through the CSAT project to determine relapse to cocaine. This project represents a broad exploratory transdisciplinary effort to better understand the clinical, behavioral and biological bases of relapse and will serve as the foundation for a future R01 submission. This study will help further our understanding of the mechanisms underlying relapse to cocaine and lead to the development of more effective relapse prevention strategies and pharmacogenetic treatments.

描述（由申请人提供）：这份 R03 拨款申请是为了回应 RFA-DA-05-004“药物滥用和其他慢性病的失效和复发”而提交的，提出了一个与临床和基础科学家合作的跨学科项目，以检查线索反应性和遗传多态性作为可卡因吸毒复发的可能病因机制的作用。这是为数不多的针对人群复发的研究之一，将基于实验室的措施与基于社区的后续行动相结合，以了解可卡因复发的生物学和行为基础。该研究的具体目的是：（1）检查未吸毒的可卡因依赖的线索反应个体是否比非反应个体更容易复发； (2)确定多巴胺和β-内啡肽途径候选基因多态性的可卡因依赖个体与没有多态性的个体相比，线索引发的渴望反应是否显着不同； (3)确定具有遗传多态性的个体是否比没有遗传多态性的个体更容易吸食可卡因。该拟议项目将是现有五年期药物滥用治疗中心 (CSAT) 授予 Drs. 的“附加项目”。 Smelson 和 Kline 提供的资金截至 2009 年。CSAT 拨款的目标是 550 名患有药物滥用障碍的人在新泽西州退伍军人事务部医疗保健系统 (VANJ) 接受治疗。拟议的 R03 将招募一个由 105 名已确诊可卡因依赖的非裔美国男性组成的小组，他们已加入 CSAT 项目。招募参加 R03 研究的人员将接受基线评估、线索暴露程序、抽血进行基因分析和尿液毒理学筛查。受试者将在基线后六个月通过 CSAT 项目使用成瘾严重程度指数和尿液毒理学筛查进行重新评估，以确定可卡因复发情况。该项目代表了一项广泛的探索性跨学科努力，旨在更好地了解复发的临床、行为和生物学基础，并将作为未来 R01 提交的基础。这项研究将有助于进一步了解可卡因复发的机制，并导致开发更有效的复发预防策略和药物遗传学治疗。