ARTERIAL ENDOTHELIAL FUNCTION--AN EPIDEMIOLOGIC STUDY

动脉内皮功能——流行病学研究

基本信息

批准号：
7440198
负责人：
TRUDY L BURNS
金额：
$ 74.14万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-12-15 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7440198
关键词：
Adhesions Adult Affect Age Age-Years Aging Animals Apolipoprotein E Apolipoproteins B Arterial Fatty Streak Arteries Atherosclerosis Bile Acids Blood Platelets Blood Pressure Blood Vessels Blood coagulation Body Size Calcium Cardiovascular Diseases Carotid Arteries Carotid Artery Diseases Carotid Stenosis Child Childhood Cholesterol Coronary Coronary artery Coronary heart disease Development Diabetes Mellitus Dilatation - action Disease Disease regression Elderly Electron Beam Tomography Endothelial Cells Enzymes Epidemiologic Studies Female Folate Functional disorder Future Generations Genetic Genotype Grant High Density Lipoprotein Cholesterol Homocysteine Homocystine Homozygote Human Hyperhomocysteinemia In Vitro Individual Inflammation Intervention Intervention Trial Investigation LDL Cholesterol Lipoproteins Lesion Life Lipids Lipoprotein (a)Low-Density Lipoproteins Measurement Measures Medial Mediating Mediator of activation protein Metabolic Metabolism Methylenetetrahydrofolate reductase (NADPH)Monkeys Mutation Oxidants Particle Size Pathogenesis Pathological Dilatation Plasma Platelet aggregation Play Population Predictive Value Process Process Measure Production Property Risk Risk Factors Role Sampling Smoke Smoking Stimulation of Cell Proliferation Stress Symptoms Therapeutic Therapeutic Intervention Thick Time Triglycerides Vascular Diseases Vasodilator Agents Vasomotor Vitamin B 12 Vitamin B6 Youth absorption apolipoprotein E-4 brachial artery calcification carbene cardiovascular risk factor cerebrovascular cohort coronary artery calcification design experience hypercholesterolemia improved lipid transport macrophage male monocyte oxidation oxidized low density lipoprotein particle response shear stress thermostability young adult

项目摘要

Many young adult subjects have some degree of atherosclerotic coronary and carotid artery disease and experience no symptoms. As time passes, many die suddenly and unexpectedly and only limited therapeutic options are available once symptomatic coronary heart disease and stoke occur. Since the atherosclerotic process begins in youth, a measure of the early manifestations of atheroscleosis may have the potential of identifying subjects at risk for premature coronary and carotid occlusive vascular disease when therapeutic options can be administered. Impaired brachial artery flow mediated dilatory (FMD) capacities have been shown to exist in children and young adults with hypercholesterolemia, hyperhomocysteinemia, diabetes and in those who smoke. Impaired brachial artery FMD has been shown to relate to impaired endothelial function, which is an early manifestation of the atherosclerotic process. If impaired brachial artery FMD is a predictor of the process, then it may be used to non-invasively assess atherosclerosis early in its development and to evaluate the effect of therapeutic interventions. In a cohort of 600 adults, 35 to 43 years of age, from the Muscatine Study, whose risk factors were measured during childhood and young adulthood, we propose to measure contemporaneous risk factors, and brachial artery FMD, along with coronary artery calcification (CAC) and carotid artery intimal-medial thickness (IMT) (the latter two established measures of early atherosclerosis) and again 3 years later. This effort is designed to examine the following hypotheses: 1) Established risk factor levels measured in childhood, adulthood and across the years from childhood through adulthood are predictive of brachial artery FMD; 2) Putative risk factor levels measured in adulthood are related to the degree of brachial artery FMD, CAC and carotid artery IMT; 3) Brachial artery FMD, CAC and carotid artery IMT are related in adults; and 4) Brachial artery FMD is predictive of increased carotid artery IMT. This application is a revision of one previously submitted as a supplement to another grant.

许多年轻成年受试者有一定程度的动脉粥样硬化冠状动脉和颈动脉疾病，没有症状。随着时间的流逝，许多人突然而出乎意料地死亡，只有限制治疗有症状的冠心病并发生了史对，就可以使用选择。自动脉粥样硬化过程始于年轻人，对动脉粥样硬化的早期表现的度量可能具有治疗时，确定患有过早冠状动脉和颈动脉闭塞血管疾病的受试者可以管理选项。臂动脉流介导的扩张（FMD）的能力受损已有证明存在于患有高胆固醇血症的儿童和年轻人中在那些抽烟的人。肱动脉FMD受损已证明与内皮功能受损相关，这是动脉粥样硬化过程的早期表现。如果跑步动脉受损，FMD是然后，该过程可以用来非侵入性地评估动脉粥样硬化的早期和评估治疗干预措施的影响。在穆斯卡汀研究中，有600名成年人（35至43岁）的队列中，其危险因素被测量在儿童和成年期间，我们建议衡量同时的危险因素和臂动脉FMD以及冠状动脉钙化（CAC）和颈动脉内膜厚度（IMT）（后两个建立了早期动脉粥样硬化的措施），并在3年后再次。这项工作是设计的检查以下假设：1）在儿童期，成年和从童年到成年的多年来，都可以预测肱动脉FMD； 2）假定风险成年后测得的因子水平与肱动脉FMD，CAC和颈动脉的程度有关 IMT; 3）成年人的臂动脉FMD，CAC和颈动脉IMT相关； 4）臂动脉FMD是可预测颈动脉IMT的增加。该申请是对先前提交的作为另一赠款的补充的修订。