NEW METHODOLOGIES FOR THE DESIGN OF SMALL BLOOD PUMPS

小型血泵设计的新方法

• 批准号: 7460231
• 负责人: GERSON ROSENBERG
• 金额: $ 70.89万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-15 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7460231
• 关键词: Adhesions; Adult; Affect; Artificial Heart; Biocompatible Materials; Biological Models; Blood; Blood Circulation; Blood Platelets; Complex; Computer Simulation; Devices; Engineering; Experimental Models; Fibrin; Finite Element Analysis; Heart; Hematology; In Vitro; Liquid substance; Mechanics; Methodology; Methods; Modeling; Movement; Operative Surgical Procedures; Patients; Performance; Platelet Activation; Public Health; Pump; Research; Stress; Surface; System; Techniques; Testing; Time; Work; blood pump; design; experience; improved; in vitro Model; in vivo; size; transmission process; ventricular assist device

DESCRIPTION (provided by applicant): The objective of this research is to make pulsatile heart replacement systems available to smaller adult patients. This is a non-trivial matter, because reduction in the size of a pulsatile blood pump affects (1) the fluid dynamics of the pump, (2) the energetics of the pump and actuator, and (3) the stresses experienced by the blood contacting materials. Thus, we consider studies such as those described here to be critical to the availability of artificial hearts and pulsatile ventricular assist devices for the full spectrum of patients. We propose to study the underlying principles of pump size reduction through three specific aims: FIRST, Utilize an integrated method of CFD modeling, experimental fluid dynamics techniques, in vitro testing and in vivo studies to significantly improve reduced size blood pumps and energy converter designs utilizing physical design constraints. These modeling and in-vitro studies will be used to predict system performance. The significance of these findings will be assessed through in vivo studies in calves. Thrombogenesis will be assessed through hematology studies, platelet activation studies, and explant analysis. Platelet and fibrin adhesion will be quantified by post explant gross exam, histological examination and multi-scale surface analysis. SECONDLY, we have developed relationships governing energetic performance of the system, utilizing a computer simulation of the energy converter, blood pump, circulation, controller, and energy transmission system. We will tailor control of actuator movement to improve fluid mechanics. The results of these studies will also be evaluated in-vitro and in-vivo. THIRDLY, we will refine and utilize improved FEA models necessary for predicting and minimizing stresses in biomaterials, so that durability of reduced-size devices is not adversely affected by pump scaling. We expect that this research will be broadly applicable to pulsatile blood pump design, especially by improving our understanding of the relationships between surface effects, fluid dynamics, and thrombogenesis in a complex, time-varying flow field. This work requires a multi-disciplinary effort in surgery, engineering, fluid mechanics, and hematology, with the means to efficiently manufacture blood pump systems and carry out the necessary in vitro and in vivo studies. PUBLIC HEALTH RELEVANCE: This research combines computational fluid dynamics, experimental fluid dynamics, systems modeling, finite element analysis, in vitro and in vivo techniques to develop a comprehensive method for the design of small blood pumps.

描述（由申请人提供）：这项研究的目的是使较小的成年患者可用的脉动心脏替代系统。这是一个非平凡的问题，因为脉冲血泵的大小减少会影响（1）泵的流体动力学，（2）泵和执行器的能量，以及（3）血接触材料所经历的压力。因此，我们认为此处描述的研究对全部患者的人造心脏和脉冲心室辅助设备的可用性至关重要。我们建议通过三个特定目的研究泵尺寸降低的基本原理：第一，利用CFD建模的集成方法，实验流体动力学技术，体外测试和体内研究，以显着改善利用物理设计约束的尺寸血液泵和能量转换器。这些建模和体外研究将用于预测系统性能。这些发现的重要性将通过犊牛的体内研究来评估。血栓形成将通过血液学研究，血小板激活研究和外植体分析进行评估。血小板和纤维蛋白的粘附将通过外植后检查，组织学检查和多尺度表面分析来量化。其次，我们利用了能源转换器，血泵，循环，控制器和能量传输系统的计算机模拟，建立了控制系统能量性能的关系。我们将调整对执行器运动的控制以改善流体力学。这些研究的结果还将评估体内和体内。第三，我们将完善并利用改进的FEA模型，以预测和最小化生物材料的应力，以使降低尺寸设备的耐用性不会受到泵缩放的不利影响。我们预计这项研究将广泛适用于脉动血泵设计，尤其是通过提高我们对复杂，随时间变化的流场中表面效应，流体动力学和血栓形成之间关系的理解。这项工作需要在手术，工程，流体力学和血液学方面做出多学科的工作，并具有有效生产血泵系统并进行必要的体外和体内研究的手段。 公共卫生相关性：这项研究结合了计算流体动力学，实验流体动力学，系统建模，有限元分析，体外和体内技术，以开发一种用于设计小血泵的综合方法。