Int'l Population on Macronutrients and BP - INTERMAP

国际人口大量营养素和血压 - INTERMAP

• 批准号: 7473205
• 负责人: JEREMIAH STAMLER
• 金额: $ 52.8万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7473205
• 关键词: Accounting; Adult; African American; Age; Alcohol consumption; All-Trans-Retinol; Amino Acids; Animals; Antioxidants; Appendix; Asians; Beta Carotene; Blood Pressure; British; Caffeine; Calcium; Carbohydrates; Chemicals; Chicago; China; Cholesterol; Collection; Copper; Cost Sharing; Country; Creatinine; Data; Data Analyses; Data Quality; Data Set; Databases; Diet; Diet Habits; Dietary Cholesterol; Dietary Factors; Dietary Fats; Dietary Proteins; Eating; Education; Ethnic Origin; Etiology; Fatty Acids; Female; Fiber; Folate; Food; Geographic Locations; Grant; Hand; Hispanics; Hour; Human; Hypertension; Individual; Intake; International; Investigation; Iron; Japan; Journals; Laboratories; Lipids; London; Macronutrients Nutrition; Magnesium; Measures; Microalbuminuria; Micronutrients; Minerals; Nicotinic Acids; Nuclear Magnetic Resonance; Nutrient; Nutrition Surveys; Omega-3 Fatty Acids; Pantothenic Acid; Participant; Pattern; Pectins; Persons; Phosphorus; Population; Population Heterogeneity; Primary Prevention; Prospective Studies; Proteins; Publishing; Recommendation; Reporting; Request for Applications; Research; Riboflavin; Risk; Role; Sample Size; Sampling; Saturated Fatty Acids; Score; Selenium; Socioeconomic Status; Source; Starch; Subgroup; Techniques; Testing; Thiamine; Time; Universities; Urea; Urine; Variant; Vegetable Proteins; Visit; Vitamin A; Vitamin B Complex; Vitamin B6; Vitamin, Other; Vitamins; Woman; Work; base; college; cost effectiveness; design; dietary starch; dietary supplements; liquid chromatography mass spectroscopy; macroalbuminuria; male; men; middle age; nutrition; polyfunctional aziridine; pressure; sex; statistics; sugar; urinary

DESCRIPTION (provided by applicant): This application requests support for further data analysis and reporting work - - including for completion of work on original and expanded aims (hypothesis testing and exploratory analyses) - - in the international cooperative INTERMAP Study. INTERMAP is a basic epidemiologic investigation on the role of dietary factors (macroland micronutrients) and their urinary metabolites in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle-aged and older individuals. A particular focus - - within the context of this overall objective - - is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population strata, e.g., in the U.S. less educated African-Americans, Hispanics, Whites. INTERMAP aims to achieve a major advance on these important issues, based on its design: large sample size of 4,680 men and women ages 40-59 from 17 diverse population samples of varied ethnicity, SES, and dietary habits in 4 countries (China, Japan, U.K., U.S.). Cost effectiveness is assured by cost sharing by London centers and inclusion here of data analysis/reporting aims from 5 on-going NHLBI supported projects. Specific aims involve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, also individual amino acids, fatty acids, sugars, vitamins, Ca, Mg, Fe, P, Cu, Se, fiber, caffeine. Primary hypotheses being tested, with control for BMI, intake of alcohol, Na, K, age, sex, other confounders are: dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-related differences in multiple dietary factors; there is a direct relation to BP of dietary SFA, cholesterol, Keys score, starch; there is an inverse relation of PFAs and of P/S. Participants, randomly selected, provided 2 timed 24-hr urine collections for assessment of Na, K, creatinine, urea, Ca, Mg, macro- and microalbuminuria, amino acids, metabolites (NMR, HPLC, MS analyses), and four 24-hr dietary recalls. BP was measured 8 times (4 visits). The study is coordinated by two Coordinating Centers - - Northwestern University, Chicago and Imperial College, London. Urinary determinations have proceeded at Central Laboratories in Leuven and London. 24-hr dietary recalls have been converted into nutrients (75 currently, 83 by mid-2004) with use of 4 country-specific up-to-date, extensive, high-quality, standardized national data bases. Findings on relations of multiple dietary factors to BP are being used to estimate favorable impact on BP of multiple improvements in nutrition by populations. This, in turn, should aid in enhancing dietary recommendations for primary prevention o1 hypertension, and for shifting BP distributions downward to avoid excess risk associated with present unfavorable levels.

描述（由申请人提供）：本申请要求支持进一步的数据分析和报告工作 - 包括完成原始和扩展目标的工作（假设测试和探索性分析） - 在国际合作式Intermap研究中。映射是对大多数中年和老年人的饮食因素（Macroland微量营养素）及其尿液代谢物在不利血压（BP）水平的病因中的基本流行病学研究。在这一整体目标的背景下，一个特定的重点 - 是有助于阐明这些饮食因素在解释受过教育程度较低的人口阶层的更不利的BP模式中的作用，例如，在美国受过教育的非裔美国人较低的非裔美国人，西班牙裔，白人。 Intermap旨在基于其设计，旨在在这些重要问题上取得重大进步：从17种不同种族，SES和饮食习惯的不同人口样本中，有4,680名男女40-59岁的男女（日本，日本，日本）的饮食习惯。 ，英国，美国）。伦敦中心的成本分配可以确保成本效益，并在此包含在此数据分析/报告的目的中，来自正在进行的NHLBI支持的项目。具体目的涉及阐明对蛋白质数量和类型的BP的影响，脂质，碳水化合物，以及单个氨基酸，脂肪酸，糖，糖，维生素，CA，MG，FE，FE，P，P，CU，CU，SE，纤维，咖啡因。主要假设正在测试，并控制了BMI，摄入酒精，Na，K，年龄，性别，其他混杂因素是：饮食蛋白与BP成反比；教育与BP之间的反比关系由多种饮食因素的与教育有关的差异显着解释；与饮食SFA，胆固醇，键评分，淀粉的BP有直接关系。 PFA和P/S存在逆关系。随机选择的参与者提供了2个定时的24小时尿液收集，用于评估Na，K，肌酐，尿素，CA，MG，宏观和微珠蛋白尿，氨基酸，代谢物（NMR，HPLC，MS分析）和四个24-- 24--人力资源饮食回忆。 BP测量了8次（4次访问）。这项研究由两个协调中心 - 西北大学，芝加哥和伦敦帝国学院进行协调。在鲁汶和伦敦的中央实验室进行了尿裁决。 24小时的饮食召回已通过使用4个特定国家特定的最新，广泛，高质量的标准化国家数据基础，转化为营养素（目前为75，到2004年中83）。关于多种饮食因素与BP关系的发现，正在使用人群对BP的多种改善来估计对BP的有利影响。反过来，这应该有助于提高原发性预防O1高血压的饮食建议，并向下移动BP分布，以避免与当前不利水平相关的过多风险。