SUBJECTIVE/REINFORCING EFFECTS OF HEROIN-BENZODIAZEPINE COMBINATIONS

海洛因-苯二氮卓组合的主观/强化作用

• 批准号: 7349554
• 负责人: DONNA M PLATT
• 金额: $ 2.8万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349554
• 关键词: SUBJECTIVE; REINFORCING; EFFECTS; HEROIN; BENZODIAZEPINE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An extensive body of clinical data indicates that opioid addicts regularly abuse benzodiazepines (BZs) in conjunction with heroin or methadone maintenance therapy. Recent research suggests that this form of polydrug abuse reflects an enhancement of the abuse-related effects of heroin and other opioid agonists by BZs. In rhesus monkeys trained to discriminate heroin from saline, the conventional non-selective BZ triazolam did not share discriminative stimulus effects with heroin. Furthermore, there was no interaction between the two drugs when administered in combination up to doses that reduced rates of responding below 50 per cent of control rates. In rhesus monkeys trained under a progressive ratio schedule of i.v. drug injection, both heroin and the conventional BZ lorazepam maintained dose-dependent and reliable self-administration. Preliminary studies indicate that combining a relatively low dose of heroin with a low dose of lorazepam resulted in a significant increase in self-administration compared to either drug individually.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。大量的临床数据表明，阿片类药物成瘾者定期滥用苯二氮卓类（BZ）与海洛因或美沙酮维持疗法结合使用。最近的研究表明，这种多药滥用形式反映了BZS对海洛因和其他阿片类药物激动剂的滥用相关影响的增强。在经过歧视海洛因和盐水的恒河猴猴子中，常规的非选择性BZ三唑胺没有与海洛因共享歧视性刺激作用。此外，将两种药物组合施用的剂量降低了响应速率低于50％的控制率的剂量，两种药物之间没有相互作用。在恒河猴以渐进式比率时间表训练的恒河猴中药物注射，海洛因和常规BZ Lorazepam都保持了剂量依赖和可靠的自我服用。初步研究表明，将相对较低剂量的海洛因与低剂量的劳拉西m结合起来，与单独使用任何一种药物相比，自我给药的显着增加。