INTEGRATIVE APPROACH TO CORTICAL COGNITIVE NETWORKS

皮质认知网络的综合方法

• 批准号: 7479341
• 负责人: JOAQUIN M FUSTER
• 金额: $ 25.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479341
• 关键词: Animals; Area; Behavior; Behavioral; Brain; Cells; Cerebral cortex; Cerebrum; Chronic; Cognition; Cognitive; Color; Compatible; Computer Architectures; Coupling; Cues; Data; Depth; Diagnostic; Dimensions; Environment; Event; Fire - disasters; Foundations; Fractionation; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Hemodynamic Phenomena; Hemoglobin; Human; Image; Injection of therapeutic agent; Intelligence; Invasive; Language; Location; Measurement; Memory; Metabolic; Methods; Microelectrodes; Monkeys; Near-Infrared Spectroscopy; Neurons; Operative Surgical Procedures; Parietal; Performance; Population; Positioning Attribute; Positron-Emission Tomography; Primates; Property; Radioactive; Records; Research; Research Design; Research Personnel; Resolution; Sampling; Sensory; Short-Term Memory; Signal Transduction; Stimulus; Structure; Sum; Surface; Testing; Time; Visual; association cortex; awake; base; cell assembly; cognitive function; cognitive neuroscience; hemodynamics; infrared spectroscopy; interest; magnetic field; programs; prospective; relating to nervous system; response; sensory stimulus

This project has two major objectives. The first is to identify structural and functional properties of cognitive neuronal networks in cortex of association (prefrontal and posterior parietal) during working memory. The second objective is largely methodological: to substantiate the coupling between neural activity and hemodynamic changes in working memory. Both objectives will be pursued in the monkey by the combined use of four minimally invasive and behavior-compatible recording methods: near-infrared spectroscopy (NIRS), surface field-potential (FP) recording, local field-potential (LFP) recording, and unit-activity recording. NIRS signals and surface FPs will be recorded simultaneously with epidural probes. Unit activity and local field potentials (LFPs) will also be recorded simultaneously by means of transdural microelectrodes. Based on certain assumptions of cognitive network architecture and the spatial resolution of each method, the four methods will be used in combination to test three specific hypotheses of neural activation and hemodynamic change in the regions of interest during the performance of two working-memory tasks, spatial delayed response (DR) and non-spatial delayed matching to sample (DMS). The analysis will focus on the neural and hemodynamic activity during the retention of a sensory stimulus in working memory. NIRS, FP, and unit data will be correlated with each of the variables most relevant to the specific hypotheses to be tested: cortical location, stimulus or memorandum, task, time of trial, and level of correct performance. In the study of neural-hemodynamic coupling in cognitive function, special emphasis will be placed on the correlations between NIRS signals and electrical manifestations of cell discharge. These correlations are expected to provide crucial information on the neuronal basis of functional imaging signals, such as those obtained by BOLD fMRI, in human cognition.

该项目有两个主要目标。首先是在工作记忆过程中识别结合皮层（前额叶和后顶叶）认知神经元网络的结构和功能特性。第二个目标在很大程度上是方法论上：证实神经活动与工作记忆中血流动力学变化之间的耦合。这两个目标都将在猴子中通过四个最小侵入性和与行为兼容的记录方法的综合使用：近红外光谱（NIRS），地表磁场（FP）记录，局部磁场（LFP）记录和单位活动记录。 NIRS信号和表面FPS将与硬膜外探针同时记录。单位活性和局部场电位（LFP）也将通过跨动物微电极同时记录。基于认知网络架构的某些假设和每种方法的空间分辨率，将使用四种方法组合使用，以测试在执行两个工作记忆任务期间，感兴趣区域的三个特定假设和血液动力学变化的三个假设，即空间延迟响应（DR）和非空间延迟延迟匹配到样品（DMS）。该分析将集中于在工作记忆中保持感觉刺激期间的神经和血流动力活性。 NIR，FP和单位数据将与与要测试的特定假设最相关的每个变量相关：皮质位置，刺激或备忘录，任务，试验时间和正确的性能水平。在认知功能中神经血流动力耦合的研究中，将特别重点放在NIRS信号与细胞放电的电体现之间的相关性上。这些相关性有望提供有关功能成像信号的神经元基础的关键信息，例如在人类认知中通过BOLD FMRI获得的信息。