Characterization of leptin's antidepressant activity

瘦素抗抑郁活性的表征

基本信息

批准号：
7343154
负责人：
Xin-Yun Lu
金额：
$ 31.03万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-25 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7343154
关键词：
Address Adipocytes Adipose tissue Adult Adverse effects Affect Anhedonia Animal Model Animals Antidepressive Agents Area Behavior Behavioral Body Weight Brain Cell Proliferation Chronic Class Depressed mood Depressive disorder Desire for food Disruption Emotional Functional disorder Genetic Goals Hippocampus (Brain)Hormones Hypothalamic structure Infusion procedures Knock-out Knowledge Leptin Link Mediating Mental Depression Mental disorders Modeling Neurobiology Neurons Neurotransmitters Pathogenesis Patients Phenotype Play Population Predisposing Factor Process Regulation Research Personnel Role Selective Serotonin Reuptake Inhibitor Serotonin Signal Transduction Standards of Weights and Measures Stress Swimming System Testing Therapeutic Effect base insight leptin receptor neurogenesis neuromechanism neurotransmission novel novel therapeutics peptide hormone programs receptor response

项目摘要

DESCRIPTION (provided by applicant): Depression is one of the most common mental illnesses. However, the pathogenesis and underlying neurobiology of depression remain poorly understood and not all depressed patients respond to current available treatments. Our recent studies have identified a role for leptin a hormone secreted from adipose tissue, in emotional processes and demonstrated that leptin has the potential as a novel antidepressant. The goal of this project is to elucidate the neural mechanisms underlying the antidepressant-like effects of leptin. First, we plan to investigate the potential role of leptin in hippocampal neurogenesis. Second, the importance of leptin action on the hippocampus in emotional behaviors will be addressed using both pharmacological and genetic approaches. Third, we will investigate the functional interaction between leptin and the serotonergic system. Our main hypothesis is that leptin's antidepressant-like activity is mediated by specific brain circuits and neurotransmitters. These studies will contribute to mechanistic understanding of the role of leptin in depression and provide insights into novel therapeutic approaches for the treatment of depressive disorders.

描述（由申请人提供）：抑郁症是最常见的精神疾病之一。然而，人们对抑郁症的发病机制和潜在的神经生物学仍然知之甚少，并且并非所有抑郁症患者都对当前可用的治疗有反应。我们最近的研究确定了瘦素（一种从脂肪组织分泌的激素）在情绪过程中的作用，并证明瘦素具有作为新型抗抑郁药的潜力。该项目的目标是阐明瘦素抗抑郁样作用背后的神经机制。首先，我们计划研究瘦素在海马神经发生中的潜在作用。其次，将使用药理学和遗传学方法来解决瘦素对海马体在情绪行为中的作用的重要性。第三，我们将研究瘦素和血清素能系统之间的功能相互作用。我们的主要假设是瘦素的抗抑郁样活性是由特定的大脑回路和神经递质介导的。这些研究将有助于从机制上理解瘦素在抑郁症中的作用，并为治疗抑郁症的新治疗方法提供见解。