Harvard/Brown Anxiety Research Project (HARP)

哈佛/布朗焦虑研究项目 (HARP)

• 批准号: 7394601
• 负责人: MARTIN B KELLER
• 金额: $ 6.45万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394601
• 关键词: Adult; African American; Age; Age of Onset; Aging; Agoraphobia; Anxiety; Anxiety Disorders; Benzodiazepines; Characteristics; Clinical; Comorbidity; Data; Doctor of Medicine; Dose; Elderly; Enrollment; Event; Face; Gender; Generalized Anxiety Disorder; Guidelines; Hispanics; Impaired cognition; Impairment; Individual; Knowledge; Length; Life; Location; Longevity; Major Depressive Disorder; Mediating; Medical; Mental Depression; Minority Groups; Modeling; Moods; National Institute of Mental Health; Nature; Numbers; Outcome; Outpatients; Panic Disorder; Patients; Pattern; Pharmaceutical Preparations; Pharmacological Treatment; Physical Function; Population; Printing; Probability; Rate; Recording of previous events; Recovery; Recurrence; Research; Research Personnel; Research Project Grants; Risk; Role; Sampling; Score; Social Functioning; Social Phobia; Standards of Weights and Measures; Substance Use Disorder; Symptoms; Testing; Thinking; Time; Universities; aging population; base; disability; disease classification; ethnic minority population; falls; illness length; indexing; partial recovery; programs; prospective; psychosocial; stressor; theories; trait; two-dimensional

DESCRIPTION (provided by applicant): We propose to continue the Harvard/Brown Anxiety Research Project (HARP), a unique, naturalistic, prospective, multicenter study of 711 subjects with anxiety disorders, who were enrolled when seeking treatment at mental health outpatient settings, for an additional 5 years of f/u. This will enable us to obtain a minimum of 15 years of f/u on subjects and to incorporate new assessments and data analysis methods in order to address important unanswered questions and develop a more comprehensive picture of the longitudinal course and outcome of common anxiety disorders: panic disorder with and without agoraphobia, generalized anxiety disorder, and social phobia. Enrollment of African-American and Hispanic subjects with anxiety disorders during the first three years of this proposal will enable us to obtain a representative sample and to examine the clinical characteristics, longitudinal course, and course mediators, in unstudied ethnic minority populations. Our specific aims are to 1) examine patterns, predictors and psychosocial outcomes of anxiety course; 2) examine factors associated with the clinical course of anxiety disorders in an aging population; 3) describe somatic and psychosocial treatment received and investigate the mediating effect of somatic treatment on course; 4) examine the course of anxiety disorders in African-Americans and Hispanics; and 5) examine the utility of dimensional approaches in characterizing and understanding the nature and course of the anxiety disorders and comorbid depressive disorders. Subjects will be evaluated at annual intervals with instruments that obtain detailed information on symptom status and severity, diagnostic status, treatment received, psychosocial functioning, stressful life events, and other domains. We have added a new assessment that will allow us to examine the effects of anxiety disorders on medical disorders and disability. We have also incorporated new data analysis methods to take maximum advantage of the new data. HARP is unique in its large number of subjects, comprehensiveness of assessment, and length of prospective f/u. This proposal will obtain meaningful new knowledge about anxiety disorders as described in a substantial revision of previous aims and hypotheses using new findings from HARP and other investigators during the past 4 years. Continuation of HARP should shed new light on clinically and theoretically important, innovative questions about a group of common and impairing disorders that have not been adequately addressed by previous research, particularly within African-Americans and Hispanics.

描述（由申请人提供）：我们建议继续开展哈佛/布朗焦虑研究项目 (HARP)，这是一项独特、自然、前瞻性、多中心的研究，研究对象为 711 名患有焦虑症的受试者，这些受试者是在心理健康门诊寻求治疗时入组的，额外 5 年 f/u。这将使我们能够获得至少 15 年的主题 f/u，并采用新的评估和数据分析方法，以解决重要的未解答问题，并更全面地了解常见焦虑症的纵向过程和结果：伴有或不伴有广场恐惧症、广泛性焦虑症和社交恐惧症的惊恐障碍。在该提案的前三年招募患有焦虑症的非裔美国人和西班牙裔受试者将使我们能够获得代表性样本，并检查未经研究的少数族裔人群的临床特征、纵向病程和病程中介因素。我们的具体目标是 1) 检查焦虑过程的模式、预测因素和心理社会结果； 2）检查与老龄化人群中焦虑症临床病程相关的因素； 3）描述所接受的躯体和心理社会治疗，并研究躯体治疗对病程的中介作用； 4）检查非裔美国人和西班牙裔美国人的焦虑症病程； 5) 检查维度方法在表征和理解焦虑症和共病抑郁症的性质和病程方面的效用。每年将使用仪器对受试者进行评估，以获得有关症状状态和严重程度、诊断状态、接受的治疗、心理社会功能、压力生活事件和其他领域的详细信息。我们增加了一项新的评估，使我们能够检查焦虑症对医学疾病和残疾的影响。我们还采用了新的数据分析方法，以最大限度地利用新数据。 HARP的独特之处在于科目数量多、评估全面、前瞻性f/u长度长。该提案将获得有关焦虑症的有意义的新知识，如使用 HARP 和其他研究人员在过去 4 年中的新发现对先前的目标和假设进行实质性修订中所描述的那样。 HARP 的继续研究应该为有关一组常见和损害性疾病的临床和理论上重要的创新问题提供新的线索，这些问题尚未被先前的研究充分解决，特别是在非裔美国人和西班牙裔美国人中。