WHOLE-BODY 7 TESLA MAGNETIC RESONANCE IMAGING SYSTEM

全身 7 特斯拉磁共振成像系统

• 批准号: 7335317
• 负责人: Ravinder Reddy
• 金额: $ 200万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7335317
• 关键词: anatomy; arthritis; bioimaging /biomedical imaging; bone; brain imaging /visualization /scanning; diffusion; gait; human; joints; lead; magnetic field; magnetic resonance imaging; magnetism; method development; molecular /cellular imaging; motivation; neoplasm /cancer; neuroimaging; noise; osteoporosis; performance; perfusion; physiology; radiology; tissues; university

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Since the inception of MRI for clinical imaging and research over two decades ago, the magnetic field strength of clinical imagers has increased 20-fold from 0.15 Tesla (T) initially to 3T currently. The early recognition that image quality per unit scan time is largely determined by the intrinsic signal-to-noise ratio has driven the diffusion of commercial 3 Tesla systems which have set a new performance standard for clinical imaging. It is likely that the current trend will continue in that the next generation systems will operate at fields considerably above 3T. Initial results from a few laboratories suggest MRI and MRS at field strengths of 7-9T to have great promise by providing insight into structure, function and physiology in humans not obtainable at lower fields. Several leading institutions in the US and overseas either already have 7T whole-body systems or are on their way to acquiring ultrahigh-field scanners in the near future. However, currently there is no 7T whole-body system at the University of Pennsylvania nor are we aware of plans by neighboring institutions of commissioning such a system. In this proposal we request funds for the acquisition of a 7T whole-body MRI scanner in the Department of Radiology at the University of Pennsylvania Medical Center. We show that the proposed system will substantially enhance ongoing research in 34 R01s, one P41 and three program project grants at four centers: the Metabolic Magnetic Resonance Research and Computing Center (MMRRCC), the Center for Functional Neuroimaging (CfN), the Center for Molecular imaging (CEMI), and the Laboratory for Structural NMR Imaging (LSNI). Biomedical imaging research in these four laboratories covers a wide range of applications and new methods development involving functional brain imaging for basic and clinical neuroscience, the study of neurodegenerative and metabolic disorders, molecular imaging for cancer detection and treatment monitoring, novel approaches to cardiovascular disease and tissue perfusion, and joint and bone disease (arthritis and osteoporosis). The 7T system will be integrated into the Center for Advanced Magnetic Resonance Imaging and Spectroscopy (CAMRIS) at the University of Pennsylvania. The resource will be run by an Executive Committee (EC) under the auspices of the current CAMRIS Committee.

该子项目是利用 NIH/NCRR 资助的共享仪器补助金提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是资助机构，不一定是研究者的机构。描述（申请人提供）：自二十多年前MRI应用于临床成像和研究以来，临床成像仪的磁场强度已从最初的0.15特斯拉（T）增加到目前的3T，增加了20倍。人们早期认识到每单位扫描时间的图像质量很大程度上取决于固有的信噪比，这推动了商业 3 Tesla 系统的普及，该系统为临床成像设立了新的性能标准。目前的趋势很可能会继续下去，因为下一代系统将在远高于 3T 的领域运行。一些实验室的初步结果表明，场强为 7-9T 的 MRI 和 MRS 通过深入了解人体的结构、功能和生理学，在较低场强下无法获得，因此具有很大的前景。美国和海外的几家领先机构要么已经拥有 7T 全身系统，要么在不久的将来购买超高场扫描仪。然而，目前宾夕法尼亚大学还没有 7T 全身系统，我们也不知道邻近机构有计划启用这样的系统。在此提案中，我们请求资金为宾夕法尼亚大学医学中心放射科购买一台 7T 全身 MRI 扫描仪。我们表明，所提出的系统将大大加强正在进行的 34 个 R01、1 个 P41 和四个中心的三个计划项目资助的研究：代谢磁共振研究和计算中心 (MMRRCC)、功能神经影像中心 (CfN)、神经功能中心分子成像 (CEMI) 和结构核磁共振成像实验室 (LSNI)。这四个实验室的生物医学成像研究涵盖了广泛的应用和新方法的开发，涉及基础和临床神经科学的功能性脑成像、神经退行性和代谢性疾病的研究、癌症检测和治疗监测的分子成像、心血管疾病的新方法和组织灌注、关节和骨骼疾病（关节炎和骨质疏松症）。 7T 系统将集成到宾夕法尼亚大学高级磁共振成像和光谱中心 (CAMRIS)。该资源将由执行委员会 (EC) 在当前 CAMRIS 委员会的支持下管理。