Micromachined Single Crystal HF Arrays for Interventional Cardiology Ultrasound

用于介入心脏病学超声的微机械单晶高频阵列

• 批准号: 7220203
• 负责人: KEVIN A SNOOK
• 金额: $ 38.56万
• 依托单位: TRS TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7220203
• 关键词: Acoustics; Affect; Angioplasty; Animals; Architecture; Arteries; Atherosclerosis; Boston; Cardiology; Cardiovascular system; Cause of Death; Condition; Coronary Arteriosclerosis; Coupling; Depth; Development; Devices; Diagnosis; Elements; Exhibits; Family suidae; Frequencies; Goals; Histocompatibility Testing; Image; Imagery; Invasive; Lesion; Location; Methods; Microfabrication; Modality; Modeling; Monitor; Numbers; Pattern; Performance; Phase; Phase I Clinical Trials; Placement; Principal Investigator; Procedures; Research; Side; Solutions; Stenosis; Stents; System; Techniques; Technology; Transducers; Traumeel S; Ultrasonic Transducer; Ultrasonography; United States; Universities; clinically significant; improved; in vivo; novel; programs; radius bone structure

DESCRIPTION (provided by applicant): Atherosclerosis and coronary artery disease affect a large number of people in the United States, and is a leading cause of death. Intravascular ultrasound (IVUS) has begun to make a significant impact in diagnosis and treatment of these conditions. It has been used in lesion visualization, stent placement and stent monitoring, and has advantages over other modalities in that it is capable of distinguishing various tissue types. A number of visualization methods such as elastography and RF analysis have advanced IVUS, though these require a large bandwidth transducer. Many existing transducers do not have adequate performance, and require acoustic mirrors or are not directed in a way that provides the most clinical significance. In Phase I, TRS Technologies and Penn State University developed a micromachining method to create composite piezoelectrics using single crystals. This PMN-PT material has a very high electromechanical coupling coefficient (k33 > 90%) which provides ultrasound transducers with an inherently wide bandwidth. In the Phase I program, a single element transducer was constructed that exhibited 80% bandwidth with one acoustic matching layer, which is significantly higher than current commercial IVUS transducers. For the Phase II program, TRS proposes to build on these results by constructing an IVUS segmented annular array with broad bandwidth for use in interventional cardiology. This device would provide a three dimensional representation of the arteries, and a forward looking architecture. In the program, the array transducer will be modeled, fabricated and evaluated using in vivo animal studies.

描述（由申请人提供）：动脉粥样硬化和冠状动脉疾病会影响美国的大量人，是死亡的主要原因。血管内超声（IVU）已开始对这些疾病的诊断和治疗产生重大影响。它已用于病变可视化，支架放置和支架监测，并且比其他方式具有优势，因为它能够区分各种组织类型。许多可视化方法，例如弹性学和RF分析具有晚期IVU，尽管它们需要大型带宽传感器。许多现有的传感器没有足够的性能，需要声音镜，也没有以最具临床意义的方式指向。在第一阶段，TRS技术和宾夕法尼亚州立大学开发了一种微加工方法，可以使用单晶创建复合压电。该PMN-PT材料具有非常高的机电耦合系数（K33> 90％），可为超声传感器提供固有较宽的带宽。在I阶段程序中，构建了一个单个元素换能器，该换能器具有80％的带宽，其中一个声学匹配层明显高于当前的商业IVUS换能器。对于II期计划，TRS建议通过构建具有宽带的环形环形阵列来构建这些结果，并用于介入心脏病学。该设备将提供动脉的三维表示和前瞻性体系结构。在该程序中，将使用体内动物研究对阵列传感器进行建模，制造和评估。