Neural Substrates of Implicit Emotional Learning

内隐情绪学习的神经基础

基本信息

批准号：
7275968
负责人：
LAURA A THOMAS
金额：
$ 0.69万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-01 至 2007-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7275968
关键词：
Adult Age Amygdaloid structure Anatomy Animal Experimentation Animal Model Anxiety Disorders Area Arousal Attention Behavior Behavioral Behavioral Paradigm Brain Brain imaging Brain region Classification Cognitive Computer information processing Condition Conscious Corpus striatum structure Cues Decision Making Education Emotional Emotions Epilepsy Exhibits Fellowship Fright Functional Magnetic Resonance Imaging Future Goals Hour Human Individual Knowledge Learning Lobectomy Measures Medial Mediating Memory Names Neocortex Neurologic Neurosciences Research Organism Outcome Panic Disorder Participant Patients Performance Phase Phobic anxiety disorder Physiological Population Positioning Attribute Process Questionnaires Rate Relative (related person)Research Research Methodology Role Running Savings Scanning Score Sensory Signal Transduction Skin Snakes Specificity Spiders Standards of Weights and Measures System Task Performances Temporal Lobe Testing Time Training Traumatic Stress Disorders Unconscious Personality Factor Unconscious State Variant Weather Work auditory feedback base cognitive neuroscience conditioned fear day emotional experience emotional stimulus habit learning implicit memory indexing memory process neural circuit neuropsychiatry neuropsychological novel procedural memory relating to nervous system research study response skills

项目摘要

DESCRIPTION (provided by applicant): It known that the amygdala is critical to the acquisition of fear conditioning, but how it may influence forms of implicit learning dependent on other brain regions, such as procedural learning (dependent on the striatum) remains unknown. In a set of 3 proposed experiments, participants will perform a variant of the striataldependent implicit learning task known as the weather prediction task. Participants will be asked to predict trial outcome (emotional or neutral photos) based on cue card configuration. Learning rates, cognitive strategies, and memory consolidation (assessed in a 24-hour delayed retention test) will be analyzed as a function of emotional outcome. Skin conductance will provide an on-line index of arousal. The emotional version of the task will be run on patients with amygdala damage to test the necessity of the amygdala in mediating implicit emotional probabilistic learning. Finally, fMRI in.healthy subjects will compare brain regions activated during learning and retention as a function of task condition (emotional vs. neutral); amygdala-striatal interactions can thus be examined across training blocks. This work will advance an understanding of the role of the amygdala and its interactions and connectivity with striatal regions during implicit emotional learning by combining multiple methodological approaches with a novel behavioral paradigm.

描述（由申请人提供）：知道杏仁核对于恐惧条件的获取至关重要，但是它如何影响取决于其他大脑区域的隐性学习形式，例如程序学习（取决于纹状体）仍然未知。在一组建议的实验中，参与者将执行被称为天气预测任务的striataldald依赖性隐式学习任务的变体。将要求参与者根据提示卡配置预测试验结果（情感或中性照片）。学习率，认知策略和记忆巩固（在24小时延迟保留测试中进行评估）将作为情感结果分析。皮肤电导将提供唤醒的在线指数。该任务的情感版本将针对具有杏仁核损害的患者进行，以测试杏仁核的必要性，以调解隐性情绪概率学习。最后，健康受试者的fMRI将比较在学习和保留过程中激活的大脑区域与任务条件的函数（情绪与中性）的关系；因此，可以在训练区域进行杏仁核 - 纹状体相互作用。这项工作将通过将多种方法论方法与新颖的行为范式相结合，了解杏仁核及其与纹状体区域的相互作用以及与纹状体区域的相互作用以及与纹状体区域的连通性的理解。