Sleep, Symptoms, and Quality of Life in Adolescents during Chemotherapy

青少年化疗期间的睡眠、症状和生活质量

• 批准号: 7274592
• 负责人: Amy J Walker
• 金额: $ 3.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274592
• 关键词: Achievement; Acute; Address; Adolescence; Adolescent; Adolescent Development; Age; Area; Biological; Cancer Center; Characteristics; Chemotherapy-Oncologic Procedure; Child; Chronic Disease; Clinical; Consent; Data; Data Collection; Data Sources; Development; Developmental Process; Diagnosis; Emotional; Family; Fatigue; Future; Gender; Generic Drugs; Goals; Growth; Human; Hygiene; Intervention; Interview; Knowledge; Life; Malignant Neoplasms; Methods; Mission; Morbidity - disease rate; Mucositis; Nausea; Nausea and Vomiting; Outpatients; Pain; Pediatric Hospitals; Phase; Population Research; Preparation; Psychometrics; Public Health; Purpose; Quality of life; Questionnaires; Recruitment Activity; Research; Research Personnel; Sample Size; Sampling; Science; Self Perception; Sleep; Sleep disturbances; Symptoms; actigraphy; base; cancer diagnosis; cancer therapy; cancer type; chemotherapy; coping; critical developmental period; day; design; diaries; experience; improved; innovation; instrument; mortality; nutrition; preadolescence; prospective; psychologic; self esteem; size; social; symptom management

DESCRIPTION (provided by applicant): Specific Aims: The long-term goal of this research is to support the continuing development and improve the quality of life of adolescents with cancer receiving chemotherapy by focusing on symptom management. The purpose of this study is to describe the sleep-wake activity of adolescents undergoing outpatient chemotherapy treatment for cancer, and to explore relationships among sleep, treatment-related symptoms, and quality of life. The primary aim of this study is to describe the sleep-wake activity of adolescents with cancer receiving chemotherapy using multiple sources of data, including actigraphy, a brief "before you were sick" sleep questionnaire, diaries, the Adolescent Sleep-Wake Scale (ASWS), the Adolescent Sleep Hygiene Scale (ASHS), and interview data. Relationships will also be explored based on demographic and clinical characteristics (e.g., age, gender, cancer type, treatment phase). The purpose of the secondary aims is to explore relationships between sleep variables, symptoms, and quality of life, and to generate effect size estimates for future research. This project is relevant to NINR's mission to "understand and ease the symptoms of acute and chronic disease". Additionally, this project focuses on adolescents, an under-researched population, with greater cancer morbidity and mortality than their younger counterparts. Sample: Adolescents, 10-19 years, irrespective of type of cancer or phase of treatment, will be recruited from Legacy Emanuel Children's Hospital (LECH) and Doernbecher Children's Hospital (DCH), the two regional children's cancer centers located in Portland, OR. The anticipated sample size is 50, to be recruited over 8 months. Design and Methods: This is a prospective, cross-sectional, exploratory study. Data will be collected from assenting/consenting adolescents at two points, and the actigraph will be worn continuously for seven days. The first data collection point will involve meeting with the investigator, filling out several psychometric instruments and demographic information. The second data collection point will consist primarily of an interview. Relevance to public health: Adolescents with cancer often have trouble sleeping, in addition to other symptoms such as pain, fatigue, and nausea. Treatment can last for 2-3 years. Therefore, we must understand how to better manage adolescents' symptoms to increase their quality of life and promote healthy adolescent development.

描述（由申请人提供）：具体目的：这项研究的长期目标是支持持续发展，并通过关注症状管理来支持癌症青少年接受化疗的青少年生活质量。这项研究的目的是描述接受门诊化疗治疗癌症的青少年的睡眠效果活动，并探索睡眠，治疗相关症状和生活质量之间的关系。这项研究的主要目的是描述使用多种数据来源的癌症接受化疗的青少年的睡眠效果活性，包括Actraphy，简短的“生病之前”睡眠问卷，DICRIES，青少年睡眠量量表（ASWS），青少年睡眠卫生量表（ASW）和访谈数据。关系还将基于人口统计和临床特征（例如年龄，性别，癌症类型，治疗阶段）探索。次要目的的目的是探索睡眠变量，症状和生活质量之间的关系，并为未来的研究产生效应尺寸估计。该项目与Ninr的使命“了解和缓解急性和慢性病的症状”有关。此外，该项目的重点是青少年，这是一个与年轻同行相比，癌症发病率和死亡率更高的青少年。样本：青少年，10 - 19岁，无论癌症类型或治疗阶段如何，都将从传统的伊曼纽尔儿童医院（LECH）和Doernbecher儿童医院（DCH）（位于波特兰的两个区域儿童癌症中心）招募。预期的样本量为50，将在8个月内招募。设计和方法：这是一项前瞻性，横断面的探索性研究。数据将从两点的同意/同意青少年中收集，并且行动式将连续磨损7天。第一个数据收集点将涉及与研究人员会面，填写几种心理测量工具和人口统计信息。第二个数据收集点主要由面试组成。与公共卫生有关：癌症的青少年除其他症状（例如疼痛，疲劳和恶心）外，还没有睡眠困难。治疗可以持续2 - 3年。因此，我们必须了解如何更好地管理青少年的症状以提高生活质量并促进健康的青少年发展。