Psychobiological Reactivity in Sickle Cell Disease

镰状细胞病的心理生物学反应

• 批准号: 7263862
• 负责人: Marsha J Treadwell
• 金额: $ 14.95万
• 依托单位: CHILDREN'S HOSPITAL & RES CTR AT OAKLAND
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7263862
• 关键词: Accounting; Adhesions; Advisory Committees; Age; Behavioral Research; Biological; Biomedical Research; Blood; Bone Marrow Transplantation; California; Child; Childhood; Clinical; Clinical Psychology; Cohort Studies; Count; Daily; Development; Disease; Disease Outcome; Enrollment; Event; Family; Five-Year Plans; Frequencies; Health; Hemoglobin; Incidence; Individual; Individual Differences; Institution; Intervention; Investigation; Laboratories; Life; Life Stress; Measures; Medical Research; Medicine; Mental Health; Mentors; Mentorship; Methods; Modeling; Numbers; Otters; Outcome; Pain; Patients; Pediatric Hospitals; Physiological; Pilot Projects; Psyche structure; Psychiatry; Psychological Factors; Psychology; Purpose; Rate; Research; Research Personnel; Resources; Risk; Science; Scientist; Series; Services; Severities; Severity of illness; Sickle Cell; Sickle Cell Anemia; Symptoms; System; Testing; Training; Training Programs; Universities; abstracting; base; biobehavior; career; cohort; concept; daily functioning; design; environmental stressor; health care service utilization; insight; loris; novel; patient oriented; programs; prospective; psychobiologic; psychologic; response; sickling; social

DESCRIPTION (provided by applicant): This application describes a five-year plan of training and development for the candidate who will refocus her clinical psychology career from service and program administration to patient-oriented bio-behavioral research in sickle cell disease. This transition will occur under the primary mentorship of Dr. Tom Boyce, a highly-regarded expert in psychobiological reactivity and health outcomes. Dr. Lori Styles, an accomplished basic and clinical researcher in sickle cell disease, will serve as co-mentor. Both sponsors have mentored a number of scientists who have gone on to independent careers in biomedical research. The training program will integrate resources from the University of California-Berkeley and Children's Hospital and Research Center at Oakland, as well as diverse concepts and methods from the fields of medicine and psychology. The candidate's collaborators will supplement her training by lending their expertise in autonomic reactivity, biomedical science and psychiatry. An advisory committee of clinical scientists with distinguished contributions to psychological and medical research in sickle cell disease will provide guidance to the candidate as she broadens her focus to an academic research career. The research plan will focus on psychobiological reactivity in response to laboratory challenge, a novel individual difference variable that integrates physiological and psychological factors, for a cohort of pediatric patients with sickle cell disease. In our pilot study, a measure of autonomic reactivity was the only variable among those studied that bore a strong association with clinical disease severity for young children with sickle cell disease. The aims of the proposed research are to: (1) evaluate psycho-biological reactivity as a robust predictor of sickle pain, defined as rate of painful episodes and daily pain frequency and intensity, for children ages five to twelve with sickle cell disease; and (2) to evaluate the independent and combined influences of physiological and psychological factors on outcomes for children with sickle cell disease. This study will offer new insight into predictors of outcomes for SCD that can in turn inform the design of more effective interventions. The strengths of the institutions and the candidate combined will maximize the candidate's potential for the successful transition into a career as an independent biobehavioral scientist. (End of Abstract)

描述（由申请人提供）： 该申请描述了候选人的五年培训和发展计划，该候选人将把她的临床心理学职业重点从服务和项目管理转向以患者为导向的镰状细胞病生物行为研究。 这一转变将在主要指导下进行 汤姆·博伊斯博士是心理生物反应和健康结果方面备受推崇的专家。 洛里·斯泰尔斯 (Lori Styles) 博士是镰状细胞病领域一位卓有成就的基础和临床研究员，他将担任联合导师。 两位赞助商都指导了许多在生物医学研究领域继续独立职业的科学家。 培训项目将整合加州大学伯克利分校和奥克兰儿童医院和研究中心的资源，以及医学和心理学领域的不同概念和方法。 候选人的合作者将通过提供自主反应、生物医学和精神病学方面的专业知识来补充她的培训。 由在镰状细胞病心理和医学研究方面做出杰出贡献的临床科学家组成的咨询委员会将为候选人将重点扩大到学术研究生涯提供指导。 该研究计划将重点关注镰状细胞病儿科患者应对实验室挑战的心理生物学反应，这是一种整合生理和心理因素的新型个体差异变量。 在我们的试点研究中，自主反应性的测量是研究中唯一与患有镰状细胞病的幼儿的临床疾病严重程度密切相关的变量。 拟议研究的目的是：（1）评估心理生物反应性作为镰状细胞病的有力预测因子，镰状细胞病定义为 5 至 12 岁患有镰状细胞病的儿童的疼痛发作率以及每日疼痛频率和强度； (2) 评估生理和心理因素对镰状细胞病儿童结局的独立和综合影响。 这项研究将为 SCD 结果的预测因素提供新的见解，从而为设计更有效的干预措施提供信息。 机构和候选人的优势相结合，将最大限度地发挥候选人成功过渡到独立生物行为科学家职业的潜力。 （摘要完）