QOL, Symptoms & Management in Children with Advanced Cancer

生活质量、症状

• 批准号: 7227072
• 负责人: Lois Van Cleve
• 金额: $ 30.62万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7227072
• 关键词: Advanced Malignant Neoplasm; Affect; Age; Area; Behavior Therapy; California; Cancer Center; Caring; Child; Child Care; Clinics and Hospitals; Cluster Analysis; Cognitive; Common Terminology Criteria for Adverse Events; Daily; Data; Data Analyses; Data Collection; Data Reporting; Disease; Disease regression; Distress; Effectiveness; Elements; Emotional; Equation; Ethnic Origin; Evidence based practice; Factor Analysis; Fatigue; Growth; Health Personnel; Health Professional; Home environment; Imagery; Information Management; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Latino; Life; Life Experience; Mental Depression; Methods; Modeling; Nurses; Operative Surgical Procedures; Pain; Palliative Care; Parents; Patient Self-Report; Phase; Process; Purpose; Quality of life; Radiation; Relaxation; Reporting; Research; Sampling; Site; Symptoms; Testing; Time; Toxic effect; Week; base; cancer therapy; chemotherapy; comparison group; end of life; experience; programs; prospective; psychologic; social; statistics; symptom management; tool

DESCRIPTION (provided by applicant): Focus: quality of life, symptoms, and management of children with advanced cancer. The aims are to: 1. Evaluate the quality of life (QOL) (physical, emotional, social, spiritual, and daily activity level). 2. Examine the self-reported symptom data in relation to type of cancer, treatment (chemotherapy, surgery, or radiation) and Common Toxicity Criteria (CTC). 3. Explore commonly occurring clusters of symptoms reported by the child. 4. Examine strategies used by child, parent(s), and health care personnel to manage self-reported symptoms. 5. Analyze the trajectory of the symptoms, management effectiveness, and QOL during a 5-month period. 6. Test the fit of a preliminary sequential model of ethnicity, age, type of cancer, treatment, symptoms, management, & QOL. 7. Compare and contrast symptoms, management and QOL experienced by Latino and White children. A mixed method will be used to examine the prospective, multi-site data from a sample of 80 children, 6 through 17 years, English or Spanish speaking, with advanced cancer. Data will be collected in the hospital, clinic, or home every 2 weeks for five months (10 data points) or until end of life. Self-report data will be collected from the child for the QOL, symptoms, and management using appropriate tools. Additional management information will be obtained from the parent, chart, or nurse. Data analysis will include descriptive and inferential statistics. Additionally, the CTC and self-report data will be examined for correlation; clusters of symptoms will be examined by graphic displays, factor analysis and hierarchical cluster analysis; the trajectory of QOL, symptoms, and management effectiveness, will be analyzed by growth curves; the fit of a preliminary sequential model will be examined by multiple regression and structural equation modeling. Significance: The results of this study are imperative in providing knowledge regarding QOL, symptoms and management for evidence-based practice by nurses and other health care professionals caring for children with advanced cancer.

描述（由申请人提供）：重点：患有晚期癌症儿童的生活质量，症状和管理。目的是： 1。评估生活质量（QOL）（身体，情感，社会，精神和日常活动水平）。 2。检查与癌症类型，治疗（化学疗法，手术或放射线）和常见毒性标准（CTC）有关的自我报告的症状数据。 3。探索儿童报告的通常发生的症状簇。 4。检查儿童，父母和卫生保健人员使用的策略来管理自我报告的症状。 5。在5个月内分析症状，管理有效性和QOL的轨迹。 6。测试种族，年龄，癌症类型，治疗，症状，管理和质量的初步顺序模型的拟合度。 7.拉丁裔和白人儿童经历的比较和对比症状，管理和QoL。 一种混合方法将用于检查来自80名儿童的样本，6至17年的样本，即英语或西班牙语，患有晚期癌症。数据将在医院，诊所或家中收集一次，每2周，持续五个月（10个数据点）或直到生命的尽头。自我报告数据将使用适当的工具从孩子那里收集QOL，症状和管理。其他管理信息将从父母，图表或护士那里获得。数据分析将包括描述性和推论统计。 此外，将检查CTC和自我报告数据是否相关。症状簇将通过图形显示，因子分析和分层聚类分析来检查； QOL，症状和管理效率的轨迹将通过增长曲线分析。初步顺序模型的拟合将通过多元回归和结构方程建模来检查。意义：这项研究的结果对于提供有关护士和其他医疗保健专业人员的循证实践的知识，症状和管理的知识至关重要。

项目成果

Pain experience in children with advanced cancer.

晚期癌症儿童的疼痛经历。

• DOI: 10.1177/1043454211432295
• 发表时间: 2012
• 期刊: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
• 作者: VanCleve,Lois;Munoz,CynthiaE;Riggs,MattL;Bava,Laura;Savedra,Marilyn
• 通讯作者: Savedra,Marilyn

Symptoms in children with advanced cancer: child and nurse reports.

• DOI: 10.1097/ncc.0b013e31821aedba
• 发表时间: 2012-03
• 期刊: Cancer nursing
• 影响因子: 2.6
• 作者: Van Cleve L;Muñoz CE;Savedra M;Riggs M;Bossert E;Grant M;Adlard K
• 通讯作者: Adlard K

A glimpse into the lives of 3 children: their cancer journey.

三个孩子的生活一瞥：他们的癌症之旅。

• DOI: 10.1177/1043454210377899
• 发表时间: 2011
• 期刊: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
• 作者: Wilson,Karla;Mazhar,Wajeeha;Rojas-Cooley,Teresa;DeRosa,Veronica;VanCleve,Lois
• 通讯作者: VanCleve,Lois