CHILDREN WITH LEUKEMIA--PAIN, MANAGEMENT AND OUTCOMES

白血病儿童——疼痛、治疗和结果

• 批准号: 2035989
• 负责人: Lois Van Cleve
• 金额: $ 25.11万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2035989
• 关键词: acute leukemia; adolescence (12-20); cancer pain; cancer rehabilitation /care; child (0-11); clinical research; coping; data collection methodology /evaluation; family structure /dynamics; human subject; interview; longitudinal human study; neoplasm /cancer epidemiology; outcomes research; patient care management; pediatric neoplasm /cancer

The purpose of this study is to examine pain in children with acute leukemia following initial diagnosis, focusing on pain experience, management strategies, and outcomes. The aims are to: 1) describe the pain of children for one year following diagnosis of acute leukemia; 2) describe the strategies used by children and their families to manage pain associated with acute leukemia; 3) examine the differences in pain before and after pain management strategies are used; 4) explore the predictors of pain outcomes; and 5) explore the relationships between pain, management, and outcomes. The knowledge gained will be vital toward developing intervention protocols for use by children, adolescents and parents seeking to manage pain associated with leukemia. It will also provide instruments translated to Spanish for use in other settings. Using a longitudinal design, 114 children, ages 4 through 16 years, will be studied from four pediatric oncology treatment centers in California. The children will be of any ethnicity, speak either English or Spanish, have any type of acute leukemia, be within 2-4 weeks of diagnosis and will not have a known cognitive disability, additional chronic illness associated with pain, fulminating disease process at diagnosis, or be unable to cope with participation in the research process. Two methods will be used to collect data. First, seven in-depth interviews plus self-report instruments will be used to elicit comprehensive data from the child and parent about the pain experience, management strategies, and outcomes. This includes inquiries regarding the location, intensity, frequency, quality, and temporal nature of pain; management strategies; and outcomes relating to pain status and functional status. Second, the child/parent will complete a home pain diary for four 5-day periods during a one year period. To encourage subject retention, interim phone and mail contact will be made with the child/parent. Data analysis will include descriptive statistics, content analysis, factor analysis, repeated measures ANOVA, regression analysis, path analysis, and discriminant function analysis.

这项研究的目的是检查急性儿童的疼痛 初次诊断后的白血病，专注于疼痛经历， 管理策略和结果。目的是：1）描述 诊断出急性白血病后，儿童疼痛一年； 2） 描述儿童及其家人使用的策略 与急性白血病有关的疼痛； 3）检查疼痛的差异 使用疼痛管理策略之前和之后； 4）探索 预测疼痛结果的因素； 5）探索 痛苦，管理和结果。获得的知识对 制定干预方案，以供儿童，青少年和 寻求管理与白血病有关的疼痛的父母。它也会 提供翻译成西班牙语的仪器以在其他设置中使用。 使用纵向设计，114名4至16岁的儿童将 从加利福尼亚的四个儿科肿瘤治疗中心进行研究。 孩子们会有任何种族，说英语或西班牙语， 有任何类型的急性白血病，在诊断后的2-4周内 不会有已知的认知障碍，额外的慢性病 与疼痛相关，诊断时充满疾病过程或 无法应付参与研究过程。 两种方法将用于收集数据。首先，七个深度 访谈以及自我报告工具将用于引起 来自孩子和父母的全面数据，涉及疼痛经历， 管理策略和结果。这包括有关 疼痛的位置，强度，频率，质量和时间性质； 管理策略；以及与疼痛状况有关的结果和 功能状态。第二，孩子/父母将完成家庭痛苦 在一年的时间内进行四个5天的日记。鼓励 主题保留，临时电话和邮寄联系将与 孩子/父母。 数据分析将包括描述性统计，内容分析， 因子分析，重复测量方差分析，回归分析，路径 分析和判别功能分析。