Biointerface Engineering to Direct Cell Migration

直接细胞迁移的生物界面工程

• 批准号: 7222425
• 负责人: Jordan S. Miller
• 金额: $ 3.96万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7222425
• 关键词: Actins; Address; Adhesives; Affect; Behavior; Biological Process; Bypass; Cell Adhesion; Cell Survival; Cells; Complex; Cytoskeleton; DNA Sequence Rearrangement; Dependence; Dermis; Development; Engineering; Extracellular Matrix; Extravasation; Facility Construction Funding Category; Fellowship; Fiber; Fibronectins; Focal Adhesions; Future; Gold; Hair follicle structure; Individual; Investigation; Jordan; Lasers; Leukocytes; Ligands; Mammalian Cell; Methods; Metric; Microscope; Modeling; Movement; Names; Natural regeneration; Neoplasm Metastasis; Organ; Pattern; Peptides; Process; Proteins; Resolution; Role; Scanning; Signal Transduction; Social Dominance; Stress Fibers; Substrate Interaction; Surface; Sweat Glands; System; Techniques; Tissue Engineering; Tissues; Today; Work; angiogenesis; cell motility; concept; islet; lithography; migration; monolayer; novel; preference; prevent; two-dimensional; wound

DESCRIPTION (provided by applicant): Cell adhesion and migration are important biological functions that critically impact such processes as wound regeneration, cancer metastasis, leukocyte extravasation, and angiogenesis. Thus, the ability to elucidate and direct cell-substrate interactions becomes increasingly essential as ongoing progress is made toward engineering tissue and organ replacements. Even today, though regenerated dermis serves a crucial role as an environmental barrier, it still lacks more subtle features of native tissue such as hair follicles and sweat glands. Work to better elucidate fundamental parameters controlling cell adhesion and migration is warranted as they are essential for tissue development and remodeling. In this proposal, we will probe the effects of multiple simultaneous ligands and micropatterned adhesive islets on cell adhesion and migration on two-dimensional surfaces.

描述（由申请人提供）：细胞粘附和迁移是重要的生物学功能，对伤口再生、癌症转移、白细胞外渗和血管生成等过程产生严重影响。因此，随着组织和器官替代工程的不断进展，阐明和指导细胞-基质相互作用的能力变得越来越重要。即使在今天，尽管再生真皮作为环境屏障发挥着至关重要的作用，但它仍然缺乏毛囊和汗腺等天然组织的更微妙的特征。有必要更好地阐明控制细胞粘附和迁移的基本参数，因为它们对于组织发育和重塑至关重要。在本提案中，我们将探讨多个同时配体和微图案粘附胰岛对二维表面上细胞粘附和迁移的影响。

项目成果

Fabrication of Multifaceted Micropatterned Surfaces with Laser Scanning Lithography.

• DOI: 10.1002/adfm.201100297
• 发表时间: 2011-08-09
• 期刊: Advanced functional materials
• 影响因子: 19
• 作者: Slater JH;Miller JS;Yu SS;West JL
• 通讯作者: West JL