X-ray imaging using edge-on-microchannel plate detectors

使用边缘微通道板探测器进行 X 射线成像

基本信息

批准号：
7061611
负责人：
SABEE MOLLOI
金额：
$ 24.34万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7061611
关键词：
X ray bioengineering /biomedical engineering bioimaging /biomedical imaging biomedical equipment development calcification charge coupled device camera computed axial tomography computer program /software electromagnetic radiation image enhancement imaging /visualization /scanning mammography monitoring device radiation dosage radiography radiology

项目摘要

DESCRIPTION (provided by applicant): A diagnostic X-ray imaging system is required to simultaneously have high contrast, high resolution and be fast with low dose to the patient. High contrast and low dose requirements are of a particular interest in mammography, where low contrast tumors and microcalcifications are to be detected at high scatter levels. The limitations of the currently scanning slot systems include the inherently high noise level of the CCD, suboptimal conversion efficiency, limited charge capacity of the CCD and its relatively high scatter fraction (up to 20%) due to its wide scanning slot. The purpose of this project is to develop a scanning multi-slit X-ray imaging system based on an "edge-on" illuminated microchannel plate (MCP) detector for potential application in mammography. The advantages of an "edge-on" MCP detector over other types of X-ray detectors are the possibility to combine high stopping power, superior spatial resolution, direct energy-tocharge conversion, high physical charge amplification and very low noise. More specifically, the aims are: (1) Design and development of a scanning slit X-ray imaging system based on "edge-on" MCP detector and delay line electronics for digital mammography. (2) Investigation of the hypothesis that an X-ray imaging system based on "edge-on" MCP detector can offer substantially improved detection quantum efficiency, resolution, noise and scatter fraction as compared to other currently available mammography systems. (3) Design and development of chip level application specific integrated circuit (ASIC) electronics with very highcount rate capability. (4) Development and evaluation of a clinically applicable single slit prototype X-ray imaging system based on "edge-on" MCP detector with ASIC electronics. (5) Design of a clinically applicable multi-slit x-ray imaging system for digital mammography. The proposed multi-slit X-ray imaging system based on an "edge-on" MCP detector will be photon counting, quantum limited and low scatter fraction. It can potentially provide a high-resolution detector with significant reduction in patient dose for digital mammography.

描述（由申请人提供）：诊断 X 射线成像系统需要同时具有高对比度、高分辨率和快速且对患者剂量低的特点。高对比度和低剂量要求在乳房X线照相术中特别重要，其中低对比度肿瘤和微钙化需要在高散射水平下检测到。当前扫描槽系统的局限性包括CCD固有的高噪声水平、次优转换效率、CCD的有限电荷容量以及由于其宽扫描槽而导致的相对较高的散射分数（高达20%）。该项目的目的是开发一种基于“边缘”照明微通道板 (MCP) 探测器的扫描多缝 X 射线成像系统，以在乳腺 X 线摄影中潜在应用。与其他类型的 X 射线探测器相比，“边缘式”MCP 探测器的优点是可以结合高阻止能力、卓越的空间分辨率、直接能量到电荷转换、高物理电荷放大和极低的噪声。更具体地说，目标是： (1) 设计和开发基于“边缘式”MCP 探测器和数字乳腺 X 线摄影延迟线电子器件的扫描狭缝 X 射线成像系统。 (2) 研究以下假设：与其他当前可用的乳腺 X 线摄影系统相比，基于“边缘”MCP 探测器的 X 射线成像系统可以提供显着改进的检测量子效率、分辨率、噪声和散射分数。 (3) 具有极高计数率能力的芯片级专用集成电路（ASIC）电子器件的设计和开发。 (4) 基于带有 ASIC 电子器件的“边缘式”MCP 探测器的临床适用单缝原型 X 射线成像系统的开发和评估。 (5)临床适用的数字乳腺X线摄影多缝X射线成像系统的设计。所提出的基于“边缘”MCP 探测器的多缝 X 射线成像系统将具有光子计数、量子限制和低散射分数。它有可能提供一种高分辨率探测器，显着减少数字乳房X光检查的患者剂量。