Medical Adhesive for Trauma-Free Bandage Removal

用于无创伤去除绷带的医用粘合剂

• 批准号: 7127852
• 负责人: Janice Paige Buchanan
• 金额: $ 17.6万
• 依托单位: UNIVERSITY OF SOUTHERN MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127852
• 关键词: Adhesives; Animal Model; Animals; Artificial skin; Award; Bandage; Biocompatible; Chemicals; Condition; Development; Elderly; Engineering; Event; Excision; Exhibits; Exposure to; Film; Fullerenes; Funding; Glass; Grant; Healed; Health; Human; In Situ; Infection; Kinetics; Letters; Light; Localized; Maryland; Mechanics; Medical; Methods; Mississippi; Modeling; Molecular; Monitor; Morphology; Oxygen; Patients; Performance; Photosensitizing Agents; Phototoxicity; Polymers; Property; Radiation; Rate; Reaction; Reactive Oxygen Species; Research; Research Personnel; Risk; Science; Screening procedure; Seeds; Skin; Standards of Weights and Measures; Sterile coverings; Structure; System; Technology; Temperature; Testing; Time; Trauma; United States National Institutes of Health; Universities; Veterinary Medicine; Virginia; Visible Radiation; Work; Wound Healing; adhesive polymer; base; biocompatible polymer; college; crosslink; design; experience; frailty; fullerene C70; healing; improved; interest; nanomaterials; polybutadiene; professor; programs; prototype; reaction rate; response; skin irritation; transmission process; vapor

DESCRIPTION (provided by applicant): Wound healing technologies are growing rapidly, and advanced dressings are continuing to accelerate healing rates, reduce infection, and significantly improve patient comfort. Each year new dressings are introduced; however, there still exists a need for strongly adhering bandage dressings that will reduce the risk of skin trauma associated with repeated use and skin frailties. This requirement is most important to very young and advancing age patients - where minimizing skin trauma is paramount. This project proposes the development of a new biocompatible polymer - nanomaterial adhesive system which is capable of being switched from a strongly adhering contact (on) state to a low-adhering release (off) state, when activated by visible light. These releasable adhesives would exhibit a significant reduction in peel strength on activation, which results in reduced localized trauma upon removal when compared to conventional dressings. The specific aims of the project include the (1) design and synthesis of new biocompatible acrylic adhesives containing fullerene active compositions; (2) addition of nanomaterials into polymeric systems and optimize additive concentration; (3) radiation crosslinking and monitoring of molecular events - optimize radiation kinetics and light power; (4) characterization of new adhesives - assess the influence of molar mass increase in the mechanical performance as a function of temperature; (5) determination of the moisture vapor transmission rate of prototypes, using the upright-cup test method; and (6) initial screening to estimate skin irritation and phototoxicity of prototype adhesives using an artificial skin model. Addition of fullerene sensitizers and exposure to visible light induces morphology changes in the polymer adhesive due to in-situ generated chemical species, which initiate crosslinking reactions. During this effort, we will also test for the first time the newly discovered metallic nitride fullerene (MNF) species as cross-linking polymer additives. The rate of reactions in this study will be controlled (1) by the percent of additive and (2) by visible light exposure time and lamp power. Adhesive mechanical properties will be evaluated by standard peel and shear tests. Glass transitions, storage and loss modulus will be determined by DSC and DMA analysis.

描述（由申请人提供）：伤口愈合技术正在迅速增长，高级敷料正在继续加速愈合率，减少感染并显着改善患者舒适性。每年都会介绍新的敷料；但是，仍然需要强烈粘附的绷带敷料，这将减少与重复使用和皮肤脆弱有关的皮肤创伤的风险。这一要求对于非常年轻的年龄患者来说是最重要的 - 在最小化皮肤创伤至关重要的情况下。该项目提出开发新的生物相容性聚合物 - 纳米材料粘合剂系统，该系统能够从强烈的粘附接触（ON）状态转换为可见光时的低粘附释放（OFF）状态。这些可释放的粘合剂将显示出激活的果皮强度显着降低，与常规调味料相比，切除后局部创伤减少了。该项目的具体目的包括（1）设计和合成含有富勒烯活性成分的新生物相容性丙烯酸粘合剂； （2）将纳米材料添加到聚合系统中并优化添加浓度； （3）分子事件的辐射交联和监测 - 优化辐射动力学和光功率； （4）新粘合剂的表征 - 评估机械性能随温度函数的摩尔质量增加的影响； （5）使用直立杯测试方法确定原型的水分蒸气传递速率； （6）使用人造皮肤模型的初始筛选以估计原型粘合剂的皮肤刺激和光毒性。富勒烯敏化剂的添加和暴露于可见光会引起由于原位产生的化学物种而引起的聚合物粘合剂的形态变化，从而启动交联反应。在这项工作中，我们还将首次测试新发现的金属氮化物富勒烯（MNF）物种作为交联聚合物添加剂。这项研究中的反应速率将通过添加剂的百分比和（2）通过可见光曝光时间和灯功率来控制（1）。粘合剂机械性能将通过标准果皮和剪切测试评估。玻璃转变，存储和损耗模量将通过DSC和DMA分析确定。

项目成果

Selective complexation and reactivity of metallic nitride and oxometallic fullerenes with Lewis acids and use as an effective purification method.

• DOI: 10.1021/ic9017147
• 发表时间: 2009-12-21
• 期刊: INORGANIC CHEMISTRY
• 影响因子: 4.6
• 作者: Stevenson, Steven;Mackey, Mary A.;Pickens, Jane E.;Stuart, Melissa A.;Confait, Bridget S.;Phillips, J. Paige
• 通讯作者: Phillips, J. Paige

Evidence for singlet-oxygen generation and biocidal activity in photoresponsive metallic nitride fullerene-polymer adhesive films.

• DOI: 10.1021/am900008v
• 发表时间: 2009-04
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: McCluskey, D. Michelle;Smith, Tiffany N.;Madasu, Praveen K.;Coumbe, Curtis E.;Mackey, Mary A.;Fulmer, Preston A.;Wynne, James H.;Stevenson, Steven;Phillips, J. Paige
• 通讯作者: Phillips, J. Paige