Quantifying and Tracking Risk for Substance Use Disorder

量化和跟踪药物使用障碍的风险

• 批准号: 7022916
• 负责人: LEVENT KIRISCI
• 金额: $ 12.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022916
• 关键词: adolescence (12-20); behavioral /social science research tag; case history; child mental disorders; clinical research; developmental psychology; disease /disorder etiology; disease /disorder proneness /risk; family genetics; gene environment interaction; human subject; mathematical model; pathologic process; peer group; psychological tests; psychometrics; questionnaires; racial /ethnic difference; social psychology; statistics /biometry; substance abuse epidemiology; substance abuse related disorder; technology /technique development

DESCRIPTION (provided by applicant): The overarching aim of this Independent Scientist Award (K02) application is to develop skills in genetics and epidemiology, and enhance my expertise in quantitative methodology pertaining to substance use disorder (SUD) etiology. The goal of the research program in the next five years is to integrate statistical and psychometric methods for deriving a practical and valid assessment of SUD liability. Employing item response theory, in conjunction with longitudinal multivariate modeling, the product of the proposed research is a continuous scale that quantifies individual risk for SUD at ages 10-12, 16, 19, and 22. This scale will be a provisionally validated self-administered questionnaire that can be used in routine assessment of youth and young adults for identifying those in need of intervention. Two versions will be developed and compared: paper and pencil for group screening and computer adaptive testing for individual assessment. To achieve this project goal, I will access the Center for Education on Drug Abuse Research (CEDAR) database consisting of multidisciplinary protocols for measurement of SUD risk. In this center grant, where I direct the Methodology and Statistics Core, psychological and environmental risk factors are prospectively studied from childhood to adulthood. The education and training component will prepare me for an R01 that is directed at standardizing the SUD liability scale derived in this research in the context of a genetic epidemiological paradigm. In this manner, etiology from the standpoint of gene-environment interactions will be investigated using the SUD liability scale provisionally derived in this project and simultaneously standardized for practical application. The long-term career goal will thus be to apply my psychometric and statistical expertise to develop instrumentation that clarifies SUD etiology and conjointly has practical utility.

描述（由申请人提供）：该独立科学家奖（K02）的总体目的是发展遗传学和流行病学的技能，并增强了与药物使用障碍（SUD）病因有关的定量方法学专业知识。在未来五年中，研究计划的目标是整合统计和心理测量方法，以得出对SUD责任的实际评估。拟议研究的产物使用项目响应理论，结合纵向多元建模，是一个连续的量表，可量化10-12、16、19、19和22岁的SUD风险。该量表将是一项临时验证的自我管理的问卷，可用于常规评估年轻人和年轻人的常规评估。将开发和比较两个版本：用于组筛选的纸和铅笔，以及用于个人评估的计算机自适应测试。为了实现这一项目目标，我将访问由毒品滥用研究教育中心（CEDAR）数据库，该数据库由多学科协议组成，用于测量SUD风险。在我指导方法和统计核心的中心赠款中，从小到成年，对心理和环境风险因素进行了前瞻性研究。教育和培训组成部分将使我为R01做好准备，该R01旨在在遗传流行病学范式的背景下在本研究中得出的SUD责任量表进行标准化。以这种方式，将使用该项目中暂时得出的SUD责任量表从基因环境相互作用的角度进行病因，并同时标准化用于实际应用。因此，长期职业目标将是运用我的心理测量和统计专业知识来开发阐明SUD病因和共同实用性的工具。