Phenogenetics of Liability to Substance Use Disorders

物质使用障碍的表观遗传学

• 批准号: 7111806
• 负责人: MICHAEL M VANYUKOV
• 金额: $ 12.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7111806
• 关键词: behavioral genetics; clinical research; family genetics; gene environment interaction; gene interaction; genetic polymorphism; genetic susceptibility; human subject; longitudinal human study; neural plasticity; neurogenetics; phenotype; quantitative trait loci; substance abuse related disorder

DESCRIPTION (provided by applicant): Variation in the risk for abuse of and dependence on illicit substances (substance use disorders, SUD) is determined by multiple genetic and environmental factors. The etiology and pathogenesis of these complex disorders involve many facets of biological function (e.g., biochemical, physiological, behavioral, etc.), effects of abusable drugs on brain neurochemistry, and multiple environmental influences, and unfold throughout the life. Contribution of and interactions between these systems at the genetic level, as well as with environmental factors, need to be taken into account in research to comprehensively explicate SUD. The overarching aim of this Independent Scientist Award (K02) application is to integrate neurobiological, genetic, psychological and environmental information to elucidate the individual trajectory to SUD. Emphasis is placed on improving understanding of the relation between genetic and neurobiological processes as components of individual liability. To achieve this goal, expertise will be acquired in the developmental neurobiology of SUD that can be integrated with advanced genetic analysis of complex traits. Research will thus focus on empirically-based selection of genes within candidate neurobiological systems, and analysis of their association with the risk for SUD using quantitative trait indices of liability. To conduct this interdisciplinary research, I will access the consolidated database of Center for Education on Drug Abuse Research's (CEDAR; P50DA005605) and its genetic grogram, R01DA019157 "Substance Use Disorder Liability: Candidate Gene Systems" (CGS) consisting of multidisciplinary family data encompassing genetic, biochemical, psychological, psychiatric and environmental factors prospectively in target children at ages 10-12, 16, 19, and 22. The applicant is the Center's Co-Pi and Scientific Director as well as PI of the CGS project.

描述（由申请人提供）： 滥用滥用风险和对非法物质的依赖（物质使用障碍，SUD）的变化是由多种遗传和环境因素决定的。这些复杂疾病的病因和发病机理涉及生物功能的许多方面（例如，生化，生理，行为等），可滥用药物对脑神经化学的影响以及多种环境影响，以及在整个生活中展开。这些系统在遗传水平以及与环境因素之间的贡献和相互作用需要在研究中考虑到全面解释SUD。 该独立科学家奖（K02）应用的总体目的是整合神经生物学，遗传，心理和环境信息，以阐明SUD的个体轨迹。重点是提高人们对遗传和神经生物学过程之间关系的理解，这是个人责任的组成部分。为了实现这一目标，将在SUD的发育神经生物学中获得专业知识，这些神经生物学可以与复杂性状的先进遗传分析集成在一起。因此，研究将集中于候选神经生物学系统中基于经验的基因选择，并分析其与使用责任定量性状指数的相关性。 To conduct this interdisciplinary research, I will access the consolidated database of Center for Education on Drug Abuse Research's (CEDAR; P50DA005605) and its genetic grogram, R01DA019157 "Substance Use Disorder Liability: Candidate Gene Systems" (CGS) consisting of multidisciplinary family data encompassing genetic, biochemical, psychological, psychiatric and environmental factors prospectively在10-12、16、19和22岁的目标儿童中。申请人是该中心的Co-PI和科学主任以及CGS项目的PI。