SCIENTIFIC CORE

科学核心

基本信息

批准号：
7618710
负责人：
MICHAEL M VANYUKOV
金额：
$ 23.78万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-01 至 2009-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7618710
关键词：
Accounting Adolescence Affect Affective Age Age of Onset Alcohol or Other Drugs use Behavior Behavioral Biological Budgets Categories Child Childhood Class Classification Clinic Clinical Collaborations Conceptual Domain Condition Data Databases Development Diagnostic and Statistical Manual Disease Doctor of Philosophy Drug usage Environment Environmental Risk Factor Etiology Family Goals Grouping Heterogeneity Individual Informal Social Control Information Systems Intelligence Intervention Studies Laboratories Left Measurement Medical Metabolism Methodology Mission Modeling Monitor Neurocognition Neurocognitive Outcome Pathogenesis Pathway interactions Personal Satisfaction Personnel Management Persons Pharmaceutical Preparations Phenotype Population Population Attributable Risks Prevention Process Program Development Protocols documentation Psychopathology Relative (related person)Research Research Activity Resolution Risk Schools Score Screening procedure Severities Socialization Stress Temperament Testing Time TimeLine Validation Variant Work base biobehavior biopsychosocial coping endophenotype experience implementation research indexing infancy instrument member neurochemistry peer psychologic reproductive self esteem social statistics theories trait

项目摘要

The Scientific Core oversees CEDAR's investigative work and is responsible for the Center's strategic program development. This Core unifies the Center's research activities, enabling the Center's vertical integration, and formulates a long-term center-wide common scientific mission. Implementation of research protocols is managed via close collaboration with the Research Modules and Clinical Core. In conjunction with the Administrative Core, research activities are maintained on an ongoing basis with respect to timelines, budget, and personnel management. All the Center's research modules and cores provide information and support for achieving center-wide goals, facilitated by the common database managed by the Computing and Information Systems Core. The analyses of the center-wide specific aims are coordinated in conjunction with the Methodology and Statistics Core. The Scientific Core, through bi-weekly meetings, monitors scientific progress toward achieving the center-wide specific aims, which are: (1) Derive a continuous index of SUD liability in late childhood and adolescence; (2) Test the theory that magnitude of behavioral and affective dysregulation in childhood resulting from the interaction between biological maturation and environmental stress, predicts substance involvement and SUD outcomes; and (3) Explore the possibility of deriving variants of SUD.

科学核心负责雪松的调查工作，并负责该中心的战略计划开发。该核心统一了中心的研究活动，实现了中心的垂直整合，并制定了一项长期的中心范围的普通科学任务。通过与研究模块和临床核心密切合作来管理研究方案的实施。结合行政核心，在时间表，预算和人事管理方面持续维持研究活动。该中心的所有研究模块和核心都为实现中心范围的目标提供了信息和支持，这是由计算和信息系统核心管理的通用数据库促进的。中心范围的特定目标的分析与方法和统计核心结合在一起。科学核心通过每两周一次的会议来监视实现中心范围特定目标的科学进步，这是：（1）在儿童后期和青春期中得出苏德责任的连续指数；（2）测试从生物成熟与环境压力之间相互作用引起的行为和情感失调的大小，可以预测物质的参与和SUD结果。（3）探索得出SUD变体的可能性。