Trajectories of Depression and Alcohol Use in Black and White Adolescent Girls

黑人和白人青春期女孩的抑郁和酗酒轨迹

• 批准号: 7183715
• 负责人: SARAH E. DAUBER
• 金额: $ 7.42万
• 依托单位: PARTNERSHIP TO END ADDICTION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7183715
• 关键词: African American; adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; caucasian American; child behavior; child mental disorders; child psychology; clinical research; comorbidity; depression; female; health behavior; human data; longitudinal human study; mental health epidemiology; parent offspring interaction; racial /ethnic difference

DESCRIPTION (provided by applicant): The proposed study aims to examine trajectories of depressive symptoms and alcohol use in White and African American adolescent girls from the early adolescent years through the transition to adulthood. This study will also examine characteristics of the parent-adolescent relationship as potential predictors of different trajectories. The specific aims of the study are to 1) examine race-specific developmental trajectories of the comorbidity of depression and substance use in adolescent girls from the early high school years through the transition to adulthood; and 2) determine whether family relationship variables predict particular trajectories of substance use and depression for adolescent girls of different racial backgrounds. To accomplish this, we will use data from the National Longitudinal Studies of Adolescent Health, a nationally representative dataset of adolescents that includes a variety of measures of frequency and severity of alcohol use, as well as an abridged version of the Center for Epidemiologic Studies Depression Scale, a widely used and well-validated measure of depressive symptoms. The dataset also includes a large number of measures of different aspects of the parent-adolescent relationship, as well as measures of a large number of potential covariates, including demographic and structural variables, peer relationships, school performance, delinquency and antisocial behavior, and self-esteem and personality variables. Data analyses will involve the use of a newly-developed approach for analyzing longitudinal data, which will allow us to group participants into distinct clusters based on their trajectories of depression and alcohol use over time, and to examine family variables as predictors of trajectory group membership. These analyses will be complemented by a more traditional hierarchical linear modeling approach. The findings of this study will increase our understanding of individual differences in patterns of depressive symptoms and alcohol use and their co-occurrence in White and African American adolescent girls. The study will also provide information on race differences in family-level risk factors for different trajectories of depression and alcohol use. Ultimately, findings will demonstrate a broader public health value in their utility in informing the design of culturally-sensitive prevention programs for depression and alcohol use in adolescent girls. The broad goals of the project are consistent with reducing mental health problems and substance use in adolescents.

描述（由申请人提供）：拟议的研究旨在研究白人和非裔美国青春期女孩从青春期早期到成年过渡的抑郁症状和饮酒轨迹。这项研究还将探讨父母与青少年关系的特征作为不同轨迹的潜在预测因素。该研究的具体目的是：1）检查青春期女孩从高中早期到成年过渡期间抑郁症和药物滥用共病的种族特定发展轨迹； 2）确定家庭关系变量是否可以预测不同种族背景的青春期女孩的药物滥用和抑郁的特定轨迹。为了实现这一目标，我们将使用来自国家青少年健康纵向研究的数据，这是一个具有全国代表性的青少年数据集，其中包括各种饮酒频率和严重程度的衡量标准，以及流行病学研究中心抑郁症的删节版量表，一种广泛使用且经过充分验证的抑郁症状测量方法。该数据集还包括大量父母与青少年关系不同方面的衡量标准，以及大量潜在协变量的衡量标准，包括人口和结构变量、同伴关系、学校表现、犯罪和反社会行为以及自我-自尊和人格变量。数据分析将涉及使用新开发的方法来分析纵向数据，这将使我们能够根据参与者随时间推移的抑郁和饮酒轨迹将他们分为不同的集群，并检查家庭变量作为轨迹组成员的预测因素。这些分析将得到更传统的分层线性建模方法的补充。这项研究的结果将加深我们对抑郁症状和饮酒模式的个体差异及其在白人和非裔美国青春期女孩中同时发生的理解。该研究还将提供有关不同抑郁和饮酒轨迹的家庭层面风险因素的种族差异信息。最终，研究结果将证明其具有更广泛的公共卫生价值，可以为针对青春期女孩抑郁症和酗酒的文化敏感预防计划的设计提供信息。该项目的总体目标与减少青少年的心理健康问题和药物滥用是一致的。

项目成果

Race-specific transition patterns among alcohol use classes in adolescent girls.

青春期女孩饮酒类别中特定种族的过渡模式。

• 发表时间: 2011-06
• 影响因子: 3.8
• 作者: Dauber, Sarah E;Paulson, James F;Leiferman, Jenn A
• 通讯作者: Leiferman, Jenn A

Typologies of alcohol use in White and African American adolescent girls.

白人和非裔美国少女的饮酒类型。

• 发表时间: 2009
• 影响因子: 2
• 作者: Dauber, Sarah;Hogue, Aaron;Paulson, James F;Leiferman, Jenn A
• 通讯作者: Leiferman, Jenn A

Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice.

预防性丙戊酸治疗可预防 Disc1-L100P 突变小鼠的精神分裂症相关行为。

• 发表时间: 2012
• 影响因子: 3.7
• 作者: Lipina, Tatiana V;Haque, Fahmida Nipa;McGirr, Alexander;Boutros, Paul C;Berger, Thorsten;Mak, Tak W;Roder, John C;Wong, Albert H C
• 通讯作者: Wong, Albert H C