MRI IN CHILDHOOD NEUROPSYCHIATRIC DISORDERS

儿童神经精神疾病中的 MRI

• 批准号: 7122890
• 负责人: BRADLEY S PETERSON
• 金额: $ 12.29万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122890
• 关键词: Tourette' s syndrome; abnormal involuntary movement; attention deficit disorder; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain morphology; child mental disorders; clinical research; developmental disease /disorder; developmental neurobiology; embryo /fetus toxicology; gestational age; human data; image processing; impulsive behavior; magnetic resonance imaging; method development; nervous system disorder; neuroanatomy; neurobiology; neurochemistry; neuropathology; nuclear magnetic resonance spectroscopy; obsessive compulsive disorder; patient oriented research

DESCRIPTION (provided by applicant): The overarching aim of this program of research is to use Magnetic Resonance Imaging (MRI) methodologies to identify the neurobiological basis of developmental neuropsychiatric disorders, and in several disease areas in particular: 1) Disorders of impulse control, including Tourette's syndrome (TS), Obsessive-Compulsive Disorder (OCD), and Attention-Deficit/Hyperactivity Disorder (ADHD); 2) Conditions that confer risk for disturbances in development of the neonatal brain, including premature birth and prenatal exposure to drugs of abuse; and 3) Affective Disorders. A substantial portion of his work also involves the development of new methods for processing MRI data and for translational research involving behavioral neuroscience paradigms within the MRI scanner, as well as mentoring junior investigators in the application of neuroimaging methodologies to the study of childhood psychiatric disorders. The immediate aims of this Career Development Award (K02) are to (1) obtain sufficient salary support to allow the applicant to continue using MRI methods to define the neurobiological bases of childhood neuropsychiatric disorders; (2) free the applicant of substantial clinical, teaching, and administrative responsibilities, thereby permitting a greater focus of time and energy on research activities; (3) provide the applicant with the opportunity to develop skill sets in MR Spectroscopy (MRS), an MRI modality with which he has only limited experience, but one that promises to reveal further the neurochemical underpinnings of morphological and functional disturbances that the applicant has helped to define in TS, OCD, and ADHD; and (4) conduct an already-funded morphometric study (R01) of 620 children and adults with TS, OCD, or ADHD and to correlate those morphological measures with immunological, neurohumoral, neuropsychological, and family history data.

DESCRIPTION (provided by applicant): The overarching aim of this program of research is to use Magnetic Resonance Imaging (MRI) methodologies to identify the neurobiological basis of developmental neuropsychiatric disorders, and in several disease areas in particular: 1) Disorders of impulse control, including Tourette's syndrome (TS), Obsessive-Compulsive Disorder (OCD), and Attention-Deficit/Hyperactivity Disorder (ADHD); 2）赋予新生儿大脑发育障碍风险的条件，包括早产和产前暴露于滥用药物中； 3）情感障碍。他的很大一部分工作还涉及开发用于处理MRI数据的新方法，以及涉及MRI扫描仪内行为神经科学范式的翻译研究，以及指导初级研究者在儿童精神疾病的研究中应用神经成像方法。该职业发展奖（K02）的直接目的是（1）获得足够的薪水支持，以使申请人继续使用MRI方法来定义儿童神经精神疾病的神经生物学基础； （2）释放申请人的大量临床，教学和行政责任，从而使时间和精力更加集中在研究活动上； （3）为申请人提供了开发MR光谱学（MRS）的技能集的机会，MRI模式仅具有有限的经验，但有望进一步揭示申请人在TS，OCD和ADHD中有助于定义的形态和功能性障碍的神经化学基础； （4）对620名具有TS，强迫症或ADHD的儿童和成人进行了已经资助的形态计量学研究（R01），并将这些形态学指标与免疫学，神经肿瘤，神经心理学和家族史数据相关联。