Navigator coronary magnetic resonance

导航冠状动脉磁共振

• 批准号: 7095717
• 负责人: Yi Wang
• 金额: $ 40.3万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095717
• 关键词: angiocardiography; angiocardioultrasonography; angiography; atherosclerotic plaque; bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; clinical research; computer program /software; contrast media; coronary artery; coronary disorder; heart disorder diagnosis; heart motion; human subject; image enhancement; image processing; magnetic resonance imaging; noninvasive diagnosis

DESCRIPTION (provided by applicant): The broad objective of this research is to develop magnetic resonance imaging (MRJ) techniques that will accurately detect significant lesions in the coronary arteries. MRI offers many advantages over CT and x- ray angiography for imaging coronary artery disease, including rich and adjustable contrasts between different tissues, noninvasive procedures, no use of ionizing radiation, and no risk of nephrotoxicity. Prior studies have demonstrated the feasibility of imaging both the coronary lumen and wall, but diagnostic accuracy is still impaired by motion artifacts. Coronary MR Angiography (MRA) technology is rapidly evolving. Studies in the prior funding cycle have led to several key findings. SSFP has been identified as the best sequence for coronary MRA because of its high SNR efficiency and fast imaging speed. Real time navigator gating provides higher spatial resolution and image quality than breath-holding for coronary MRA. There is still inconsistency in coronary MRA quality because of the use of electrocardiogram and the diaphragm navigator echo, neither of which directly measures coronary motion. We have recently developed the coronary fat navigator method that allows direct and accurate monitoring of coronary motion. Accordingly, we propose here to develop the coronary fat navigator for SSFP coronary MRA to achieve effective motion suppression. We have also developed a simultaneous multiple volume (SMV) algorithm for efficient navigator gating. Preliminary data demonstrate that the SMV algorithm shortens navigator gated scan time by 2-3 fold. Accordingly, we propose to incorporate SMV gating into navigator coronary MRA to shorten scan time. We have also obtained preliminary experience in imaging coronary vessel walls. The navigator technology can be directly employed to reduce motion blurring artifacts in high resolution plaque imaging, which would provide valuable information for characterizing atherosclerotic plaque in coronary arteries. This research consists of two specific aims: 1) develop an efficient and effective navigator method for imaging the coronary lumen and wall; and 2) evaluate the developed coronary MRI in patients with coronary artery disease by comparing to conventional x-ray angiography and intravascular ultrasound.

描述（由申请人提供）：本研究的主要目标是开发能够准确检测冠状动脉中显着病变的磁共振成像（MRJ）技术。与 CT 和 X 射线血管造影相比，MRI 在冠状动脉疾病成像方面具有许多优势，包括不同组织之间丰富且可调节的对比度、非侵入性操作、不使用电离辐射以及无肾毒性风险。先前的研究已经证明了对冠状动脉腔和壁进行成像的可行性，但诊断准确性仍然受到运动伪影的影响。冠状动脉磁共振血管造影 (MRA) 技术正在迅速发展。上一个资助周期的研究得出了几项重要发现。 SSFP因其高信噪比效率和快速成像速度而被认为是冠状动脉MRA的最佳序列。实时导航门控为冠状动脉 MRA 提供比屏气更高的空间分辨率和图像质量。由于使用心电图和膈肌导航回波，两者都不能直接测量冠状动脉运动，因此冠状动脉 MRA 质量仍然不一致。我们最近开发了冠状动脉脂肪导航器方法，可以直接准确地监测冠状动脉运动。因此，我们在此建议开发用于 SSFP 冠状动脉 MRA 的冠状脂肪导航器，以实现有效的运动抑制。我们还开发了一种同步多体积 (SMV) 算法，用于高效的导航器门控。初步数据表明，SMV 算法将导航器门控扫描时间缩短了 2-3 倍。因此，我们建议将 SMV 门控纳入导航冠状动脉 MRA 中，以缩短扫描时间。我们在冠状动脉血管壁成像方面也取得了初步经验。导航器技术可直接用于减少高分辨率斑块成像中的运动模糊伪影，这将为表征冠状动脉中的动脉粥样硬化斑块提供有价值的信息。这项研究包括两个具体目标：1）开发一种高效且有效的导航器方法来对冠状动脉腔和壁进行成像； 2) 通过与传统 X 射线血管造影和血管内超声进行比较，评估冠状动脉疾病患者的冠状动脉 MRI。