2006 CARDIAC REGULATORY MECHANISMS GORDON CONFERENCE

2006 年心脏调节机制戈登会议

• 批准号: 7113240
• 负责人: KENNETH PHILIPSON
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113240
• 关键词: cardiovascular function; cardiovascular system; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on July 16-21, 2006. This GRC has a long history of providing a format for discussion of cutting edge science by talented and productive scientists from different disciplines, all with a common interest in the topic of regulation of the normal and diseased heart. A key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that creates productive discussions and exchanges of novel ideas, where everyone is encouraged to participate. The special informal nature of the GRC has through the years been a focal point for the generation of new ideas and for new personal and scientific connections. The GRC is also a place for young and established investigators to have meaningful interactions. This is an exciting time in cardiovascular science because of the advent of novel technologies that allow us to explore the cellular and molecular bases of normal cardiac function. We are beginning to translate these new findings to a better understanding of disease mechanisms, diagnosis, prevention and treatment. This GRC has had a good mix of fundamentalscience related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The GRC proposed for 2006 will expand upon these themes to discuss a number of important topics. The conference will include sessions dedicated to the role of Ca in cell signaling and in the regulation of cardiac contractility, the latest breakthroughs in the structure and function of Ca regulatory proteins and their roles in cardiac diseases, and on excitation-contraction coupling and rhythm generation. One day will be spent discussing the influence of Ca as a modulator of cardiac growth, injury, myocyte death and hypertrophy. A related session will discuss the latest attempts at repairing failing hearts with stem cells and inducing normal patterns of gene expression. The keynote address at the end of the conference will be given by Dr. Andrew McColloch on the interface between creative mathematical modelling and cardiac regulatory pathways. All sessions will include late breaking science (from poster contributions) and as always, there will be ample time for poster sessions and informal interchange of ideas.

描述（由申请人提供）： 本申请为将于 2006 年 7 月 16 日至 21 日在科尔比索耶学院（新罕布什尔州科尔比索耶）举行的关于心脏调节机制的戈登研究会议 (GRC) 寻求部分资助。该 GRC 长期以来为心脏调节机制提供了一种格式。来自不同学科的才华横溢、多产的科学家对尖端科学的讨论，他们都对正常和患病心脏的调节主题有共同的兴趣。本次会议的一个主要目标是营造包容、激烈、活跃、互动的氛围，创造富有成效的讨论和新颖想法的交流，鼓励每个人都参与其中。多年来，GRC 特殊的非正式性质一直是产生新想法以及建立新的个人和科学联系的焦点。 GRC 也是年轻和成熟的研究人员进行有意义的互动的地方。这是心血管科学的一个激动人心的时刻，因为新技术的出现使我们能够探索正常心脏功能的细胞和分子基础。我们开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。该 GRC 很好地融合了与正常心脏电和机械特性的调节、心肌细胞信号传导以及导致心脏功能障碍的这些过程中的异常相关的基础科学。 2006 年拟议的 GRC 将扩展这些主题，讨论一些重要的主题。会议将包括 会议专门讨论 Ca 在细胞信号传导和心肌收缩力调节中的作用、Ca 调节蛋白结构和功能的最新突破及其在心脏病中的作用，以及兴奋-收缩耦合和节律生成。我们将用一天时间讨论 Ca 作为心脏生长、损伤、心肌细胞死亡和肥大调节剂的影响。相关会议将讨论用干细胞修复衰竭心脏和诱导正常基因表达模式的最新尝试。会议结束时，Andrew McColloch 博士将就创造性数学模型与心脏调节途径之间的接口发表主题演讲。所有会议都将包括最新的科学成果（来自海报贡献），并且一如既往，将有充足的时间进行海报会议和非正式的思想交流。